2024-03-29T07:43:49Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00001369
2023-01-26T05:57:16Z
329:333:334:335
Estrogen Enhances Vitamin D_3-mediated Expression of Osteocalcin mRNA by Increasing Vitamin D_3 Receptor Expression in Osteoblasts
KAWANO, Setsuko
3106
KAMBE, Fukushi
3107
KANDA, Kazumi
3108
OHMORI, Sachiko
3109
SEO, Hisao
3110
estrogen
1α,25-dihydroxyvitamin D_3
osteocalcin
1α,25-dihydroxyvitamin D_3 receptor
2002-12
Regulation of osteocalcin (OC) gene expression in osteoblasts by estrogen has been controversial. We thus investigated the effect of 17β-estradiol (Ea) on 1α,25-dihydroxyvitamin D_3 (VD_3)-mediated increase in the transcription of OC gene in rat osteoblastic ROS 17/2.8 cells. Treatment of the cells with E_2 or VD_3 alone did not increase OC mRNA. However, combined treatment with E_2 and VD_3 significantly increased the OC mRNA levels, suggesting that VD_3-dependent up-regulation of OC expression requires E_2 action. Since it was demonstrated that treatment with E_2 alone increased the expression of VD_3 receptor mRNA, it was suggested that E_2- mediated increase in the receptor number is contributing to VD_3-mediated increase in OC gene transcription.
国立情報学研究所で電子化したコンテンツを使用している。
departmental bulletin paper
Research Institute of Environmental Medicine, Nagoya University
2002-12
Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University
1/2
46
43
44
http://hdl.handle.net/2237/2779
02870517
eng