2024-02-28T03:38:57Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00003948
2023-11-16T06:42:35Z
499:508:509:516
Simple exponential regression model to describe the relation between minute ventilation and oxygen uptake during incremental exercise
Baba, Reizo
10088
Mori, Emiko
10089
Tauchi, Nobuo
10090
Nagashima, Masami
10091
oxygen consumption,
ventilation
carbon dioxide
2002-11
The physiological significance of an exponential regression model between minute ventilation (VE) and . oxygen uptake (VO2) during incremental exercise was examined. Thirty-eight subjects, including 12 patients with chronic heart failure, participated in cardiopulmonary exercise testing on a bicycle ergometer. The equation VE = a ebVO2, where a and b are parameters, was used to describe the relation between VE and VO2 during incremental exercise. Arterialized blood gas analysis was measured before and during exercise. The correlation coefficient of the regression model was high (r = 0.97±0.02). Parameter a negatively correlated with the arterial partial pressure of carbon dioxide during exercise (r=-0.44, p<0.01), and positively corre-lated with peak VO2 (r=0.47, p<0.01). Parameter b negatively correlated with peak VO2 (r=-0.86, p<0.01) and positively correlated with the dead space to tidal volume ratio (r=0.68, p<0.01). The regression model, as well as parameters a and b, is physiologically useful in expressing metabolic response to exercise. This model, a specific solution to the differential equation dVE/dVO2=bVE, implies that the more a subject breathes, the greater is the increment in ventilation needed to meet a further increment of metabolic demand.
departmental bulletin paper
Nagoya University School of Medicine
2002-11
Nagoya Journal of Medical Science
3-4
65
95
102
http://hdl.handle.net/2237/5381
2186-3326
0027-7622
eng