2024-03-28T22:46:31Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00003960
2023-11-16T06:43:08Z
499:508:509:517
Transgenic rat models of vasopressin overexpression
Oiso, Yutaka
10131
Nagasaki, Hiroshi
10132
Yokoi, Hisashi
10133
vasopressin
V2 receptor
transgenic rat
downregulation
2003-11
Vasopressin has an important role in water metabolism and its impairment induces some clinical disorders such as diabetes insipidus or syndrome of inappropriate antidiuresis (SIAD). SIAD is caused by the overproduction of vasopressin which induces diluting hyponatremia. The accurate diagnosis and appropriate therapy have not settled up to date because its pathophysiology is very complicated. It is meaningful to develop a rat model of SIAD in which human vasopressin gene is overexpressed in order to analyze pathophysiological changes. Several models transgenic for vasopressin including us had been generated. The transgenic rats provide a useful model to investigate various pathophysiological changes resulting from the oversecretion of vasopressin. Some interesting results based on these animal models are reviewed.
departmental bulletin paper
Nagoya University School of Medicine
2003-11
Nagoya Journal of Medical Science
3-4
66
87
93
http://hdl.handle.net/2237/5393
2186-3326
0027-7622
eng