2024-03-28T16:48:20Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00005959
2023-01-26T06:20:21Z
329:333:334:737
Long-term Effects of Amiodarone and its Non-iodinated Analogue, Dronedarone, on the Transcription of Cardiac Sarcoplasmic Reticulum Ca^2+-ATPase Gene
Shi, Rong-qian
15866
Lee, Jong-Kook
15867
Takeuchi, Yoko
15868
Zhang, Liyan
15869
Miwa, Keiko
15870
Kambe, Fukushi
15871
Murata, Yoshiharu
15872
Kodama, Itsuo
15873
amiodarone
dronedarone
thyroid hormone
SERCA2
2003-12
Antiarrhythmic effects of long-term amiodarone is supposed to be mediated in part by cardio-selective hypothyroidism, but the issue remains controversial. We examined mRNA expression of sacroplasmic reticulum Ca^2+-ATPase(SERCA2) by Northern blot analysis in rats treated with amiodarone (60mg/kg/day, 4 weeks) or dronedarone (60mg/kg/day, 4 weeks). SERCA2 mRNA level in ventricular muscle was significantly decreased in hypothyroid rats by 38±9%(p<0.05, n=4), whereas increased in hyperthyroid rats by 39±19%(p<0.05, n=4) compared with control (euthyroid) rats. Amiodarone treatment caused a slight decrease in SERCA2 mRNA(by 20±13%, n=4), whereas dronedarone treatment caused a slight increase (by 19±23%, n=3), although the changes did not reach statistical significance. Amiodarone and dronedarone have different effects on the gene transcription of SERCA2 in the heart, suggesting their different thyroid hormone-mediated actions.
研究所で電子化したコンテンツを使用している。
departmental bulletin paper
Research Institute of Environmental Medicine, Nagoya University
2003-12
Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University
47
39
41
http://hdl.handle.net/2237/7573
0287-0517
eng