2024-03-29T12:25:22Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00005983
2023-01-26T06:22:39Z
329:333:334:737
Computer Simulation Analysis of Shock Intensity - and Phase - Dependence of High-Intensity DC Stimulation Aftereffects on Action Potential of Ventricular Muscle
Ohuchi, Katsuhiro
16010
Fukui, Yasuhiro
16011
Sakuma, Ichiro
16012
Shibata, Nitaro
16013
Honjo, Haruo
16014
Takatani, Setsuo
16015
Kodama, Itsuo
16016
defibrillation
electroporation
computer simulation
action potentials
2003-12
The shock intensity-and phase-dependence of high-intensity DC stimulation aftereffects was studied by using Luo-Rudy’s dynamic action potential model. Shock-induced transient rupture (electroporation) of the cell membrane was represented by incorporation of non-selective ionic pores. Application of DC shocks during the plateau phase caused a prolongation of the action potential. Diastolic phase shocks resulted in an activation of action potential with similar delay in repolarization. Oscillatory membrane potentials and single or multiple spontaneous excitations were induced by DC shocks with intermediate intensity and these were accompanied by activation of L-type calcium current during the plateau phase. These results are consistent with observations in animal experiments. The Luo-Rudy’s dynamic action potential model with reversible electroporation-mediated pores may provide useful tools to investigate membrane potential changes and underlying ionic mechanisms following electrical shocks.
国立情報学研究所で電子化したコンテンツを使用している。
departmental bulletin paper
Research Institute of Environmental Medicine, Nagoya University
2003-12
Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University
47
69
71
http://hdl.handle.net/2237/7600
0287-0517
eng