2024-03-29T07:20:16Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00007346
2023-01-16T03:54:30Z
643:666:667
The role of bystin in embryo implantation and in ribosomal biogenesis
FUKUDA, Michiko N
20344
MIYOSHI, Masaya
20345
NADANO, Daita
20346
BYSL
Enp1
ribosome
embryo
trophoblast
placenta
cancer
Human bystin was identified as a cytoplasmic protein directly binding to trophinin, a cell adhesion molecule potentially involved in human embryo implantation. Although the trophinin gene is unique to mammals, the bystin gene (BYSL) is conserved across eukaryotes. Recent studies show that bystin plays a key role during the transition from silent trophectoderm to an active trophoblast upon trophinin-mediated cell adhesion. Bystin gene knockout and knockdown experiments demonstrate that bystin is essential for embryonic stem cell survival and trophectoderm development in the mouse. Furthermore, biochemical analysis of bystin in human cancer cells and mouse embryos indicates a function in ribosomal biogenesis, specifically in processing of 18S RNA in the 40S subunit. Strong evidence that BYSL is a target of c-MYC is consistent with bystin’s role in rapid protein synthesis, which is required for actively growing cells.
journal article
Springer
2007
application/pdf
Cellular and Molecular Life Sciences
1
65
92
99
http://hdl.handle.net/2237/9027
1420-9071
https://nagoya.repo.nii.ac.jp/record/7346/files/CMLS-Bysl.pdf
eng
https://doi.org/10.1007/s00018-007-7302-9
The original publication is available at www.springerlink.com.