2024-03-28T20:50:47Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00011962
2023-01-16T03:58:29Z
1179:1180:1186:1259
Application of in vivo methodologies to investigation of biological structure, function and xenobiotic response in see-through medaka (Oryzias latipes)
Hardman, Ron C.
37906
Kullman, Seth. W.
37907
Hinton, David E.
37908
medaka
liver
toxicity
hepatobiliary
in vivo imaging
2007
We describe here the development and application of non invasive in vivo methodologies to the investigation of biological structure, function and xenobiotic response in see-through medaka (STII; Oryzias latipes). In vivo studies in STII medaka provided novel insights into hepatobiliary architecture, development and toxic response, in both 2 and 3 dimensions. As the presented findings suggest, STII medaka provide a unique means for high resolution in vivo study, and the future opportunity to integrate mechanisms of toxicity (e.g. genomic, proteomic information) with phenotypic changes at the system level (the overarching goal of our laboratory). While our focus has been the hepatobiliary system, other organ systems are equally amenable to in vivo study, and we consider the potential for discovery, within the context of in vivo investigation in STII medaka, as significant.
departmental bulletin paper
Laboratory of Freshwater Fish Stocks Bioscience and Biotechnology Center Nagoya University
2007
The Fish Biology Journal Medaka
11
43
65
http://hdl.handle.net/2237/13836
eng
http://ci.nii.ac.jp/naid/110007349047/
Laboratory of Freshwater Fish Stocks Bioscience and Biotechnology Center Nagoya University
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