2024-03-29T13:44:01Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00013206
2023-01-16T04:00:14Z
499:960:1165
Increased signal intensity of the cochlea on pre- and post-contrast enhanced 3D-FLAIR in patients with vestibular schwannoma
Yamazaki, Masahiro
41721
Naganawa, Shinji
41722
Kawai, Hisashi
41723
Nihashi, Takashi
41724
Fukatsu, Hiroshi
41725
Nakashima, Tsutomu
41726
magnetic resonance
FLAIR
high resolution
vestibular schwannoma
cochlea
名古屋大学
NAGOYA University
博士(医学)
Introduction: In the vestibular schwannoma patients, the pathophysiologic mechanism of inner ear involvement is still unclear. We investigated the status of the cochleae in patients with vestibular schwannoma by evaluating the signal intensity of cochlear fluid on pre- and post-contrast enhanced thin section three-dimensional fluid attenuated inversion recovery (3D-FLAIR). Methods: Twenty-eight patients were retrospectively analyzed. Post-contrast images were obtained in 18 patients and 20 patients had the records of their pure-tone audiometry. Regions of interest of both cochleae (C) and of the medulla oblongata (M) were determined on 3D-FLAIR images by referring to 3D-heavily T2-weighted images on a workstation. The signal intensity ratio between C and M on the 3D-FLAIR images (CM ratio) was then evaluated. In addition, correlation between the CM ratio and the hearing level was also evaluated. Results: The CM ratio of the affected side was significantly higher than that of the unaffected side (p<0.001). In the affected side, post-contrast signal elevation was observed (p<0.005). In 13 patients (26 cochleae) who underwent both gadolinium injection and the pure-tone audiometry, the postcontrast CM ratio correlated with hearing level (p<0.05). Conclusion: The results of present study suggest that alteration of cochlear fluid composition and increased permeability of the blood-labyrinthine barrier exist in the affected side in patients with vestibular schwannoma. Furthermore, although weak, positive correlation between post-contrast cochlear signal intensity on 3D-FLAIR and hearing level warrants further study to clarify the relationship between 3D-FLAIR findings and prognosis of hearing preservation surgery.
名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成22年9月28日 山崎雅弘氏の博士論文として提出された
doctoral thesis
Springer
2009-12
application/pdf
Neuroradiology
12
51
855
863
甲第8943号
http://dx.doi.org/10.1007/s00234-009-0588-6
http://hdl.handle.net/2237/15101
0028-3940
https://nagoya.repo.nii.ac.jp/record/13206/files/k8943.pdf
eng
https://doi.org/10.1007/s00234-009-0588-6
The final publication is available at www.springerlink.com