2024-03-29T13:51:51Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00014177
2023-11-16T06:24:19Z
499:508:509:615
ANTIBIOTIC AND EJACULATION TREATMENTS IMPROVE RESOLUTION RATE OF LEUKOCYTOSPERMIA IN INFERTILE MEN WITH PROSTATITIS
YAMAMOTO, MASANORI
44120
HIBI, HATSUKI
44121
KATSUNO, SATOSHI
44122
MIYAKE, KOJI
44123
Leukocytospermia
Infertility
Prostatitis
1995-05-27
Leukocytospermia has been associated with notable adverse effects on semen parameters and sperm function. The present study was undertaken to identify men with leukocytospermia and prostatitis in an infertility population and assess the effects of various treatments. One million white blood cells (WBC)/ml semen was defined as leukocytospermia. An expressed prostatic fluid was analyzed for the presence of white blood cells. The presence of more than 10 WBCs/high power field on expressed prostatic secretion was needed for the diagnosis of prostatitis. Those men who had more than one million WBCs in their semen and more than 10 WBCs/high power field on expressed prostatic secretion were enrolled in this study. Of two hundred sixty-three men screened for the presence of leukocytospermia and prostatitis, forty-eight men met both criteria. They were blindly and randomly assigned to one of three groups. Group 1 received no treatment. Group 2 were treated with trimethoprim 80 mg-sulfamethoxazole 400 mg (TMP-SMX) orally twice per day for one month. Group 3 were treated not only with the same antibiotic regimen as group 2 but also were instructed to ejaculate frequently (at least once every three days) for one month. Significant resolution of leukocytospermia occurred in the order of patient groups 3 > 2 > 1 at one month. The resolution rate of leukocytospermia of each group was 76% in group 3, 56% in group 2 and 6.7% in group 1. The rates in groups 2 and 3 were significantly higher than that in group 1 (p < 0.05).The resolution was sustained at two and three months in both groups 2 and 3, and a higher rate of resolution was obtained in group 3. We conclude that antibiotic with frequent ejaculation effectively treats leukocytospermia.
departmental bulletin paper
Nagoya University School of Medicine
1995-05-27
Nagoya Journal of Medical Science
1-2
58
41
45
http://hdl.handle.net/2237/16082
2186-3326
0027-7622
eng
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5812/5812.html