2024-03-29T08:00:45Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00014718
2023-01-16T04:02:06Z
499:960:1165
Postprandial hypotension: hemodynamic differences between multiple system atrophy and peripheral autonomic neuropathy
Hirayama, M
45404
Watanabe, H
45405
Koike, Y
45406
Hasegawa, Y
45407
Kanaoke, Y
45408
Sakurai, N
45409
Hakusui, S
45410
Takahashi, A
45411
Postprandial hypotension
Cardiac output
Hemodynamics
Multiple system atrophy
Autonomic neuropathy
名古屋大学
NAGOYA University
博士(医学)
To clarify the mechanism of postprandial hypotension (PPH), we performed hemodynamic investigation after oral glucose ingestion in ten patients with multiple system atrophy (MSA), three patients with peripheral autonomic neuropathy (PN) and 16 normal controls. Blood pressure (BP) and heart rate (HR) were measured with an automatic sphygmomanometer; cardiac out (CO) and lower leg blood flow (LBF) with impedance plethysmography; and portal blood flow (PBF) using a B-mode pulse Doppler. In normal subjects, BP, LBF and vascular resistance of the lower leg (LVR) were not changed, but HR slightly increased, and PBF and CO significantly increased after oral ingestion of 75 g glucose. In the patients with MSA, BP fell significantly 15 min after glucose ingestion, and HR and CO did not increase. PBF and LBF increased and LVR fell significantly. In PN patients, BP decreased at 15 min after glucose ingestion, but soon recovered. Increase of PBF and decrease of LVR in them were almost similar to those in the MSA group, and increase of CO was greater than that in the controls. These results suggest that both systemic vasodilatation (presumably due to gastrointestinal vasodilatatory peptides) and lack of compensatory increase of CO and LVR play important roles in PPH.
名古屋大学博士学位論文 学位の種類 : 博士(医学)(論文) 学位授与年月日:平成5年1月28日 平山正昭氏の博士論文として提出された
doctoral thesis
Elsevier
1993-04
application/pdf
Journal of the Autonomic Nervous System
1
43
1
6
乙第4331号
http://dx.doi.org/10.1016/0165-1838(93)90315-L
http://hdl.handle.net/2237/16641
0165-1838
https://nagoya.repo.nii.ac.jp/record/14718/files/o4331.pdf
eng
https://doi.org/10.1016/0165-1838(93)90315-L
This is the author's version of a work that was accepted for publication in Journal of the Autonomic Nervous System. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms, may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of the Autonomic Nervous System. v.43, n.1, 1993, p.1–6 DOI: 10.1016/0165-1838(93)90315-L