2024-03-29T11:53:22Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00014785
2023-01-16T04:02:12Z
499:960:1165
Proliferating cell nuclear antigen expression in papillary thyroid carcinoma
Ando, H
45658
Funahashi, H
45659
Ito, M
45660
Imai, T
45661
Takagi, H
45662
名古屋大学
NAGOYA University
博士(医学)
AIMS: To correlate the expression of proliferating cell nuclear antigen (PCNA) with various clinicopathological features of papillary thyroid carcinoma. METHODS: Sections from 131 formalin fixed, paraffin wax embedded papillary thyroid carcinomas were stained with a monoclonal antibody (PC10) directed against PCNA using the avidin-biotin immunoperoxidase (ABC) method. PCNA immunoreactivity was based on the PCNA labelling index (LI) following evaluation of at least 1000 tumour cells, and expressed as follows: grade A (LI < 10%), grade B (10% < or = LI < 25%), and grade C (LI > or = 25%). The relation between PCNA expression in these three groups and other clinicopathological factors, such as sex, age, tumour size, nodal metastases, and histological differentiation, were examined. RESULTS: Based on the labelling index, 57 (43.5%) cases were graded as A, 46 (35.1%) as B, and 28 (21.4%) as C. The female-:male ratios were 6.13:1 for group A, 2.83:1 for group B, and 2.11:1 for group C. The mean (SD) ages of the patients were 39.0 (16.1) in group A, 53.5 (14.4) in group B, and 55.8 (13.3) years in group C. The correlation between age and PCNA grade was strongest in women. CONCLUSIONS: PCNA immunoreactivity is correlated with sex and age in patients with papillary thyroid tumours.
名古屋大学博士学位論文 学位の種類 : 博士(医学)(論文) 学位授与年月日:平成9年2月20日 安藤広幸氏の博士論文として提出された
doctoral thesis
the BMJ Publishing Group
1996-08
application/pdf
Journal of Clinical Pathology
8
49
657
659
乙第5153号
http://hdl.handle.net/2237/16718
0021-9746
https://nagoya.repo.nii.ac.jp/record/14785/files/o5153.pdf
eng