2024-03-28T21:13:31Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00015332
2023-11-16T06:03:36Z
499:508:509:1443
Relation of the Size of Functional Hepatic Cell Mass to the Clearance of Indocyanine Green
KOJIMA, HIROHIKO
98653
1978-01
The correlation between fractional clearance (K) of indocyanine green (ICG) and size of hepatic cell mass altered by functional hepatectomy as well as the degree of hepatic damage induced by carbon tetrachloride (CCl4) was investigated in the dog. Less than 20% functional hepatectomy produced only a minimal decrease in K of ICG probably due to the potential functional reserve of the liver, while in dogs with more than 70% functional hepatectomy, K of ICG was remarkably decreased. K of ICG was correlated highly with the magnitude of functional hepatectomy, i.e. the size of remaining functional hepatic cell mass. Large doses of CCl4 induced remarkable decreases in K of ICG, being correlated positively with the degree of hepatic cell necrosis, and CCl4 in smaller doses rather activated the hepatic cell function as reflected by higher K values. It was concluded that K of ICG was a reliable indicator of function of hepatic cell mass in acute or subacute damage of the hepatic cell.
departmental bulletin paper
Nagoya University School of Medicine
1978-01
Nagoya Journal of Medical Science
1-2
40
47
55
2186-3326
0027-7622
eng
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/4012/4012.html