2024-03-29T09:06:06Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00015345
2023-11-16T06:04:09Z
499:508:509:1446
The Effect of Large Dose Intratumoral Administration of OK-432 in Advanced Cancer Patients
SAKAMOTO, JUNICHI
46761
KONDO, TATSUHEI
46762
KAMEl, HIDEO
46763
ICHlHASHl, HIDEHITO
46764
YAMAMURA, YOSHITAKA
46765
1979-12
To clarify the effect of large dose intratumoral administration of OK-432, experimental and clinical investigations were perfomed. In the experimental study, 250 KE/Kg OK-432 was administered into S-180 sarcoma in ddN mice. Mice treated by OK-432 showed significant increase in delayed hypersensitivity reaction and elongation in the survival times. In the clinical study, 50 KE OK-432 was injected intratumorally during the surgery for the advanced and inoperable malignancy. PHA and PPD skin test reactions, IgG titers, and lymphocyte counts were elevated in the group received the large dose of OK-432. The treatment seemed to contribute to the prolongation of survival times during 3 months after the operation.
departmental bulletin paper
Nagoya University School of Medicine
1979-12
Nagoya Journal of Medical Science
1-2
42
27
36
http://hdl.handle.net/2237/17363
2186-3326
0027-7622
eng
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/4212/4212.html