2024-03-29T15:45:03Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00016530
2023-11-16T05:40:12Z
499:508:509:1509
Studies on Nonprecipitating Insulin Antibody : Radioimmunoassay of Insulin Binding Capacity and Its Relationship to Insulin Neutralizing Activity and Ability to Evoke Cutaneous Anaphylactic Reaction
NAKAMURA, HIROO
96211
1968-06
Skom and Talmage have demonstrated a non-precipitating antibody against insulin in the sera of insulin-treated diabetics. But their method of determining the antibody is not quantitative. In the present study, a titration of the insulin binding activity of anti-insulin was performed more quantitatively using 131I-labeled insulin and antiguinea pig γ-globulin rabbit sera under the condition of insulin excess. Moreover, the insulin binding activity of anti-insulin was correlated with its insulin neutralizing activity and also with its ability to evoke a cutaneous anaphylactic reaction. A considerably good correlation was observed between the insulin neutralizing activity and insulin binding activity. On the other hand, between the insulin binding activity and the ability to evoke cutaneous anaphylactic reaction was only a poor correlation observed.
departmental bulletin paper
Nagoya University School of Medicine
1968-06
Nagoya Journal of Medical Science
1
31
143
153
2186-3326
0027-7622
eng
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/311/311.html