2024-03-29T07:24:19Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00016704
2023-11-16T05:31:33Z
499:508:509:1528
Effect of Tolbutamide on the Respiration of Heart Muscle Mitochondria
KATSUMATA, KAZUO
98634
HAGIHARA, MASAKO
98635
1973-03
Tolbutamide, one of the hypoglycemic sulphonylurea drugs was found to decrease the respiratory control index of beef heart mitochondria as well as that of rat liver mitochondria. The effect of the drug on beef heart mitochondria was more pronounced than on liver mitochondria in the range of concentrations of 30-80 mg%. It was of interest to find that DNP release of mitochondrial respiration was not observed after the addition of 100 mg% tolbutamide. These findings were discussed in relation to the side;effect of this drug.
departmental bulletin paper
Nagoya University School of Medicine
1973-03
Nagoya Journal of Medical Science
2-4
35
79
84
2186-3326
0027-7622
eng
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/3524/3524.html