2024-03-28T17:18:49Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00017478
2023-01-16T04:05:25Z
499:500:501
Quantification of Brain Metabolites by 1H Spectroscopy Using Cyclohexane as an External Reference
外部基準にシクロヘキサンを用いた1Hスペクトロスコピーの定量化
前田, 尚利
51362
滝, 一郎
51363
安藤, 容子
51364
松島, 秀
51365
Maeda, Hisatoshi
51366
Taki, Ichirou
51367
Ando, Yoko
51368
Matsushima, Shigeru
51369
MR spectroscopy
Quantification
We tested the reliability of quantifying brain metabolite concentrations by MR spectroscopy. We employed a PRESS sequence and used a cyclohexane sample as an external standard. The signal intensity ratios of water and cyclohexane were measured by changing the geometrical arrangement of the cyclohexane sample and water phantom with various loading factors of the coil. Choline (Cho) concentrations were calculated from the signal intensity ratios of Cho and water and compared with actual Cho concentrations (1.0 to 2.6 mmol/L). The brain metabolites Cho, creatine/phosphocreatine (Cr/PCr) and N-acetylaspartate (NAA) were evaluated in five normal volunteers and six patients with metastatic brain cancer before (0 Gy), after 20 Gy and after 40 Gy of whole brain radiotherapy. Variation in the ratio of spectrum intensity between water and cyclohexane was less than 1.5% for various geometrical arrangements and loading factors. The error in quantification of Cho concentrations in the phantom study was 0.05 +/- 0.10 mmol/L. The concentrations measured in the volunteers were: Cho 1.6 +/- 0.4 mmol/L, Cr/PCr 6.4 +/- 1.1 mmol/L and NAA 8.2 +/- 0.1 mmol/L. There was no significant difference (p > 0.05) in these concentrations between the control group and the patients before, during, or after radiotherapy.
journal article
日本医学放射線学会
1996-07-25
application/pdf
日本医学放射線学会雑誌
8
56
579
587
http://hdl.handle.net/2237/19564
0048-0428
https://nagoya.repo.nii.ac.jp/record/17478/files/29_Using_Cyclohexane_as_an_External_Reference.pdf
jpn