2024-03-28T21:10:01Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00021393
2023-11-17T00:53:12Z
499:508:509:1826
Diagnostic value of procalcitonin for acute complicated appendicitis
Yamashita, Hiromasa
61938
Yuasa, Norihiro
61939
Takeuchi, Eiji
61940
Goto, Yasutomo
61941
Miyake, Hideo
61942
Miyata, Kanji
61943
Kato, Hideki
61944
Ito, Masafumi
61945
procalcitonin
appendicitis
C-reactive protein
2016-02
A rapid and reliable test for detection of complicated appendicitis would be useful when deciding whether emergency surgery is required. We investigated the clinical usefulness of procalcitonin for identifying acute complicated appendicitis. We retrospectively analyzed 63 patients aged ≥15 years who underwent appendectomy without receiving antibiotics before admission and had preoperative data on the plasma procalcitonin level (PCT), body temperature (BT), white blood cell count (WBC), neutrophil / lymphocyte ratio (N/L ratio), and C-reactive protein level (CRP). Patients were classified into 3 groups: group A (inflammatory cell infiltration of the appendix with intact mural architecture), group B (inflammatory cell infiltration with destruction of mural architecture, but without abscess or perforation), and group C (macroscopic abscess and/or perforation). For identifying destruction of mural architecture, the diagnostic accuracy of PCT was similar to that of BT or CRP. However, the diagnostic accuracy of PCT was highest among the five inflammatory indices for identifying abscess and/or perforation, with the positive predictive value of PCT for abscess and/or perforation being higher than that of CRP (73% vs. 48%). Univariate analysis of the predictors of abscess and/or perforation revealed that a plasma PCT level ≥0.46 ng/mL had the highest odds ratio (30.3 [95% confidence interval: 6.5–140.5] versus PCT >0.46 ng/mL). These findings indicate that procalcitonin is a useful marker of acute appendicitis with abscess and/or perforation.
departmental bulletin paper
Nagoya University Graduate School of Medicine, School of Medicine
2016-02
Nagoya Journal of Medical Science
1
78
79
88
http://hdl.handle.net/2237/23537
2186-3326
0027-7622
eng
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/781.html