2024-03-29T13:53:33Z
https://nagoya.repo.nii.ac.jp/oai
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2023-01-16T04:11:56Z
320:321:322
Liquid-like behavior of chromatin
Maeshima, Kazuhiro
66466
Ide, Satoru
66467
Hibino, Kayo
66468
Sasai, Masaki
66469
Eukaryotic chromatin is a negatively charged long polymer composed of genomic DNA, histones, and various proteins. The charged property causes the chromatin structure to be dynamically changed. These dynamic changes are critical for genome functions such as gene expression because they directly govern the degree of DNA accessibility. Although the chromatin structure is not yet fully understood, currently increasing evidence suggests that chromatin has a dynamic liquid-like structure based on the 10-nm fiber but not the 30-nm fiber. This liquid-like property can drive the process of ‘scanning and targeting genomic DNA,’ which contributes to various genome functions including gene expression and DNA replication, repair, and recombination. Here, we discuss the liquid-like behavior of chromatin and its physical and biological relevance.
This review comes from a themed issue on Genome architecture and expression, edited by Fred Berger and Pamela Geyer
journal article
Elsevier
2016-01
application/pdf
Current Opinion in Genetics & Development
37
36
45
http://dx.doi.org/10.1016/j.gde.2015.11.006
http://hdl.handle.net/2237/24585
0959-437X
https://nagoya.repo.nii.ac.jp/record/22437/files/CurrOpnGenDev2016Maeshima.pdf
eng
https://doi.org/10.1016/j.gde.2015.11.006
(c) 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).