2024-03-29T06:55:23Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00022985
2023-01-16T04:12:37Z
499:500:501
Collective invasion of cancer: Perspectives from pathology and development
Wang, Xiaoze
67885
Enomoto, Atsushi
67886
Asai, Naoya
67887
Kato, Takuya
67888
Takahashi, Masahide
67889
cancer
collective migration
collective invasion
neuroblast
leading cell
Girdin
MRTF
Trim27
Clinical pathologists have long been aware that in many types of human malignant tumors, the cells are often connected and form groups of various sizes or “nests”. In this way, they achieve “collective invasion” into the surrounding stroma, rather than spreading out individually. Such collective behavior is also a common feature of migration during embryonic and postnatal developmental stages, suggesting there are advantages gained by collective cell migration in the organisms. Recent studies have revealed the mechanisms underlying the collective invasion of cancer cells. These mechanisms differ from those observed in the migration of single cells in culture, including reliance on the epithelial–mesenchymal transition program. Whereas intercellular adhesion appears to be coordinated, cancer cell groups can be heterogenous, including cells that are leaders and those that are followers. There is also interaction with the tumor microenvironment that is a prerequisite for collective invasion of cancer. In this review, we describe recently emerging mechanisms underlying the collective migration of cells, with a particular focus in our studies on the actin-binding protein Girdin/GIV and the transcriptional regulator tripartite motif containing 27. These studies provide new perspectives on the mechanistic analogy between cancer and development.
journal article
Wiley
2016-04
application/pdf
PATHOLOGY INTERNATIONAL
4
66
183
192
http://doi.org/10.1111/pin.12391
http://hdl.handle.net/2237/25169
1320-5463
https://nagoya.repo.nii.ac.jp/record/22985/files/Wang_et_al_Pathol_Int_2016.pdf
eng
https://doi.org/10.1111/pin.12391
This is the peer reviewed version of the following article: [Wang, X., Enomoto, A., Asai, N., Kato, T., and Takahashi, M. (2016) Collective invasion of cancer: Perspectives from pathology and development. Pathology International, 66: 183–192], which has been published in final form at [http://doi.org/10.1111/pin.12391]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.