2024-03-29T12:20:12Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00024641
2023-01-16T04:15:07Z
499:500:501
Epigenetic modulation associated with carcinogenesis and prognosis of human gastric cancer (Review)
Sonohara, Fuminori
72965
Inokawa, Yoshikuni
72966
Hayashi, Masamichi
72967
Kodera, Yasuhiro
72968
Nomoto, Shuji
72969
Gastric cancer (GC) is a leading cause of cancer‑related death, particularly in Asia. Epidemiological and other clinical studies have identified an association between a number of risk factors, including Helicobacter pylori, and GC. A number of studies have also examined genetic changes associated with the development and progression of GC. When considering the clinical significance of the expression of a specific gene, its epigenetic modulation should be considered. Epigenetic modulation appears to be a primary driver of changes in gastric tissue that promotes carcinogenesis and progression of GC and other neoplasms. The role of epigenetic modulation in GC carcinogenesis and progression has been widely studied in recent years. In the present review, recent results of epigenetic modulation associated with GC and their effects on clinical outcome are examined, with particular respect to DNA methylation, histone modulation and non‑coding RNA. A number of studies indicate that epigenetic changes in the expression of specific genes critically affect their clinical significance and further study may reveal epigenetic changes as the basis for targeted molecular therapy or novel biomarkers that predict GC prognosis or extension of this often fatal disease.
journal article
Spandidos Publications
2017-05
application/pdf
Oncology Letters
5
13
3363
3368
https://doi.org/10.3892/ol.2017.5912
http://hdl.handle.net/2237/26858
1792-1074
https://nagoya.repo.nii.ac.jp/record/24641/files/ol_13_5_3363_PDF.pdf
eng
https://doi.org/10.3892/ol.2017.5912