2024-03-28T18:00:27Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00024776
2023-01-16T04:15:14Z
1903:1904:1905
Sulfur restriction extends fission yeast chronological lifespan through Ecl1 family genes by downregulation of ribosome
Ohtsuka, Hokuto
73655
Takinami, Masahiro
73656
Shimasaki, Takafumi
73657
Hibi, Takahide
73658
Murakami, Hiroshi
73659
Aiba, Hirofumi
73660
Nutritional restrictions such as calorie restrictions are known to increase the lifespan of various organisms. Here, we found that a restriction of sulfur extended the chronological lifespan (CLS) of the fission yeast Schizosaccharomyces pombe. The restriction decreased cellular size, RNA content, and ribosomal proteins and increased sporulation rate. These responses depended on Ecl1 family genes, the overexpression of which results in the extension of CLS. We also showed that the Zip1 transcription factor results in the sulfur restriction-dependent expression of the ecl1^+ gene. We demonstrated that a decrease in ribosomal activity results in the extension of CLS. Based on these observations, we propose that sulfur restriction extends CLS through Ecl1 family genes in a ribosomal activity-dependent manner.
journal article
Wiley
2017-07
application/pdf
Molecular Microbiology
1
105
84
97
http://doi.org/10.1111/mmi.13686
http://hdl.handle.net/2237/26998
0950-382X
https://nagoya.repo.nii.ac.jp/record/24776/files/Total.pdf
eng
https://doi.org/10.1111/mmi.13686
This is the peer reviewed version of the following article: [H.Ohtsuka, M.Takinami, T.Shimasaki,T.Hibi,H.Murakami,and H.Aiba,Molecular Microbiology.v.105,n.1, 2017,p.84-97]which has been published in final form at [http://doi.org/10.1111/mmi.13686]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.