2024-03-28T20:14:56Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00025030
2023-01-16T04:15:42Z
499:500:501
Phosphorylated signal transducer and activator of transcription 3 in the epidermis in adult-onset Still’s disease
TAKEICHI, Takuya
74627
WATANABE, Naoki
74628
MURO, Yoshinao
74629
TESHIGAWARA, Shiho
74630
SATO, Motoki
74631
BAN, Nobutaro
74632
AKIYAMA, Masashi
74633
adult-onset Still’s disease
epidermis
immunohistochemistry
keratinocyte
signal transducer
Adult-onset Still's disease (AOSD) is characterized by multiple systemic inflammation of unknown etiology. Although the typical eruption of AOSD is salmon-pink rheumatoid rash on the trunk and extremities, persistent pruritic papules and plaques have also been reported. Correlations between serum cytokines, including interleukin-6 and -18, and disease activity in AOSD have been reported. Activated signal transducer and activator of transcription 3 (STAT3) is transported into the nucleus, where it functions as a transcription factor that regulates genes involved in cell survival and inflammation. To assess whether STAT3 was phosphorylated in skin samples from AOSD patients, we conducted immunohistochemical analysis of affected and unaffected lesions from four AOSD patients in comparison with 10 normal controls. Quantitative analysis was conducted by measuring the ratio of epidermal keratinocytes with phosphorylated STAT3 (p-STAT3)-positive nuclei to total epidermal keratinocytes. p-STAT3 was found to be more strongly expressed in the nuclei in the epidermis of AOSD than in normal controls. Quantification of the data revealed significant differences in staining for p-STAT3 between AOSD and normal skin. Our findings suggest that phosphorylation of STAT3 may be a potential therapeutic target for AOSD.
journal article
Wiley
2017-10
image/tiff
image/tiff
application/pdf
JOURNAL OF DERMATOLOGY
10
44
1172
1175
http://doi.org/10.1111/1346-8138.13888
http://hdl.handle.net/2237/27254
0385-2407
https://nagoya.repo.nii.ac.jp/record/25030/files/Slide_1.tif
https://nagoya.repo.nii.ac.jp/record/25030/files/Figure_02_03-14-17_trimed.tif
https://nagoya.repo.nii.ac.jp/record/25030/files/AOSD_Main_text_03-14-17.pdf
eng
https://doi.org/10.1111/1346-8138.13888
This is the peer reviewed version of the following article: [ Takeichi, T; Watanabe, N; Muro, Y; Teshigawara, S; Sato, M; Ban, N; Akiyama, M(2017),Phosphorylated signal transducer and activator of transcription 3 in the epidermis in adult-onset Still's disease. JOURNAL OF DERMATOLOGY, 44, 10: p.1172-1175], which has been published in final form at [http://doi.org/10.1111/1346-8138.13888]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.