2024-03-29T05:50:41Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00025053
2023-01-16T04:45:57Z
499:500:501
Structural MRI correlates of amyotrophic lateral sclerosis progression
Senda, Joe
74713
Atsuta, Naoki
74714
Watanabe, Hirohisa
74715
Bagarinao, Epifanio
74716
Imai, Kazunori
74717
Yokoi, Daichi
74718
Riku, Yuichi
74719
Masuda, Michihito
74720
Nakamura, Ryoichi
74721
Watanabe, Hazuki
74722
Ito, Mizuki
74723
Katsuno, Masahisa
74724
Naganawa, Shinji
74725
Sobue, Gen
74726
Amyotrophic lateral sclerosis (ALS)
progression
voxel-based mo r p ho me t r y ( V B M)
iffu s io n t e n s o r ima g in g ( D T I )
fr a c t io n a l anisotropy (FA)
Purpose Amyotrophic lateral sclerosis (ALS) presents with varying degrees of brain degeneration that can extend beyond the corticospinal tract (CST). Furthermore, the clinical course and progression of ALS varies widely. Brain degeneration detected using structural MRI could reflect disease progression. \nSubjects and methods On study registration, 3-Tesla volumetric MRI and diffusion tensor imaging scans were obtained at baseline in 38 healthy controls and 67 patients with sporadic ALS. Patients had Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) scores of ≥36 and did not have the chromosome 9, open reading frame 72 repeat expansion. Six months later, changes in ALSFRS-R (ΔALSFRS-R) scores were calculated and patients were grouped into three categories, namely, patients with slow progression with ΔALSFRS-R scores ≤3 (n=19), intermediate progression with ΔALSFRS-R scores =4, 5 and 6 (n=36) and rapid progression with ΔALSFRS-R scores ≥7 (n=12). We analysed voxel-based morphometry and tract-based spatial statistics among these subgroups and controls. \nResults In comparison with controls, patients with ALS showed grey matter atrophy and decreased fractional anisotropy beyond the motor cortex and CST, especially in the frontotemporal lobes and basal ganglia. Moreover, the degree of change was highly proportional to ΔALSFRS-R at the 6-month assessment. \nConclusion A more rapid disease progression and poorer functional decline were associated with greater involvement of the extra-motor cortex and basal ganglia, suggesting that the spatial extent of brain involvement can be an indicator of the progression in ALS.
journal article
BMJ Publishing
2017-11
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JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
11
88
901
907
http://doi.org/10.1136/jnnp-2016-314337
http://hdl.handle.net/2237/27262
0022-3050
https://nagoya.repo.nii.ac.jp/record/25053/files/Supplemental Fgure 1C.JPG
https://nagoya.repo.nii.ac.jp/record/25053/files/Supplemental Fgure 1B.JPG
https://nagoya.repo.nii.ac.jp/record/25053/files/Supplemental Fgure 1A.JPG
https://nagoya.repo.nii.ac.jp/record/25053/files/Supplemental Fgure 1.JPG
https://nagoya.repo.nii.ac.jp/record/25053/files/Figure3.jpg
https://nagoya.repo.nii.ac.jp/record/25053/files/Figure2.jpg
https://nagoya.repo.nii.ac.jp/record/25053/files/Figure1.jpg
https://nagoya.repo.nii.ac.jp/record/25053/files/Manuscript_JNNP_20180112.pdf
eng
https://doi.org/10.1136/jnnp-2016-314337
Copyright 2017 BMJ Publishing . The following article appeared in (JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. v.88, n.11, 2017, p.901-907) and may be found at (http://dx.doi.org/10.1136/jnnp-2016-314337).