2024-03-29T00:59:09Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00026421
2023-01-16T04:17:00Z
499:500:501
The clinical relevance of plasma CD147/basigin in biopsy-proven kidney diseases
Mori, Yoshiko
86908
Masuda, Tomohiro
86909
Kosugi, Tomoki
86910
Yoshioka, Tomoki
86911
Hori, Mayuko
86912
Nagaya, Hiroshi
86913
Maeda, Kayaho
86914
Sato, Yuka
86915
Kojima, Hiroshi
86916
Kato, Noritoshi
86917
Ishimoto, Takuji
86918
Katsuno, Takayuki
86919
Yuzawa, Yukio
86920
Kadomatsu, Kenji
86921
Maruyama, Shoichi
86922
CD147
Inflammation
Proteinuria
Background: Precise understanding of kidney disease activity is needed to design therapeutic strategies. CD147/basigin is involved in the pathogenesis of acute kidney injury and renal fibrosis through inflammatory cell infiltration. The present study examined the clinical relevance of CD147 in biopsy-proven kidney diseases that lead to the progression of chronic kidney disease. Methods: Kidney biopsy specimens and plasma and urine samples were obtained from patients with kidney diseases, including IgA nephropathy (IgAN), Henoch–Schönlein purpura nephritis (HSPN), diabetic kidney disease (DKD), focal segmental glomerulosclerosis (FSGS), and membranous nephropathy (MN), who underwent renal biopsy between 2011 and 2014. Plasma and urinary CD147 levels were measured and evaluated for their ability to reflect histological features. Disease activity of IgAN tissues was evaluated according to the Oxford classification and the Japanese histological grading system. Results: In biopsy tissues, CD147 induction was detected in injured lesions representing renal inflammation. Plasma CD147 values correlated with eGFR in patients with inflammation-related kidney diseases such as IgAN, HSPN, and DKD. Particularly in IgAN patients, plasma CD147 levels were correlated with injured regions comprising more than 50% of glomeruli or with tubular atrophy/interstitial injury in biopsy tissues. Proteinuria showed a closer correlation with urinary values of CD147 and L-FABP. Of note, plasma and urinary CD147 levels showed a strong correlation with eGFR or proteinuria, respectively, only in DKD patients. Conclusion: Evaluation of plasma and urinary CD147 levels might provide key insights for the understanding of the activity of various kidney diseases.
ファイル公開:2019/08/01
journal article
Springer
2018-08
application/pdf
application/pdf
application/pdf
Clinical and Experimental Nephrology
4
22
815
824
1342-1751
1437-7799
https://nagoya.repo.nii.ac.jp/record/26421/files/manuscript.pdf
https://nagoya.repo.nii.ac.jp/record/26421/files/Revised_figure.pdf
https://nagoya.repo.nii.ac.jp/record/26421/files/Revised_supplemental_figure.pdf
eng
https://doi.org/10.1007/s10157-017-1518-2
“This is a post-peer-review, pre-copyedit version of an article published in [Clinical and Experimental Nephrology]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10157-017-1518-2”.