2024-03-28T18:04:08Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00026595
2023-01-16T04:16:55Z
499:500:501
β-catenin (CTNNB1) mutation and LEF1 expression in sinonasal glomangiopericytoma (sinonasal-type hemangiopericytoma)
Suzuki, Yuka
87940
Ichihara, Shu
87941
Kawasaki, Tomonori
87942
Yanai, Hiroyuki
87943
Kitagawa, Satoshi
87944
Shimoyama, Yoshie
87945
Nakamura, Shigeo
87946
Nakaguro, Masato
87947
Sinonasal glomangiopericytoma
β-catenin
CTNNB1
LEF1
Sinonasal glomangiopericytoma (SN-GPC) is an uncommon mesenchymal tumor with myoid differentiation. Recently, mutations in exon 3 of the gene coding for β-catenin (CTNNB1) and its nuclear expression were discovered in SN-GPC. β-catenin protein is a key regulatory molecule of the canonical Wnt signaling pathway. The expression of β-catenin target proteins is not well characterized in SN-GPC. We examined three SN-GPCs by immunohistochemistry and CTNNB1 mutation analysis. All cases expressed nuclear β-catenin. We identified CTNNB1 exon 3 mutations in two analyzable cases. Lymphoid enhancer-binding factor 1 (LEF1), a protein downstream from β-catenin, was also expressed in all cases. Our results further characterized the activation of the Wnt signaling pathway caused by CTNNB1 exon 3 mutation and suggest the utility of LEF1 immunohistochemistry in the differential diagnosis of SN-GPC.
ファイル公開:2019/08/01
journal article
Springer
2018-08
application/pdf
Virchows Archiv
2
473
235
239
0945-6317
1432-2307
https://nagoya.repo.nii.ac.jp/record/26595/files/180430submission.pdf
eng
https://doi.org/10.1007/s00428-018-2370-9
“This is a post-peer-review, pre-copyedit version of an article published in [Virchows Archiv]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00428-018-2370-9”.