2024-03-28T09:07:11Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00026866
2023-01-16T04:43:43Z
499:500:501
Manganese in toenails is associated with hearing loss at high frequencies in humans
Ohgami, Nobutaka
87973
Li, Xiang
87974
Yajima, Ichiro
87975
Oshino, Reina
87976
Ohgami, Kyoko
87977
Kato, Yoko
87978
Ahsan, Nazmul
87979
Akhand, Anwarul Azim
87980
Kato, Masashi
87981
manganese
hearing loss
toenails
inner ears
ICP-MS
Purpose: Elevated hearing thresholds from high frequencies are known to be one of the hallmarks of age-related hearing loss. Our recent study showed accumulation of manganese (Mn) in inner ears resulting in acceleration of age-related hearing loss in mice orally exposed to Mn. However, there is no evidence showing an association between Mn in non-invasive biological samples and hearing loss in humans evaluated by pure tone audiometry (PTA). In this study, we evaluated Mn in non-invasive biological samples as a possible biomarker for hearing loss in humans. Materials and methods: We determined hearing levels by PTA and Mn levels in toenails, hair and urine with an inductively coupled plasma mass spectrometer (ICP-MS) in 145 healthy subjects in Bangladesh. Results: Multivariable analyses showed that Mn levels in toenails, but not in hair and urine samples, were significantly associated with hearing loss at 8 kHz and 12 kHz. Moreover, our experimental study showed a significant correlation between Mn levels in inner ears and nails, but not hair, in mice orally exposed to Mn. Conclusions: The results provide novel evidence that Mn in toenails is a possible biomarker for hearing loss at high frequencies in humans.
ファイル公開:2019/04/10
journal article
Taylor & Francis
2018-04-10
application/pdf
Biomarkers
6
23
533
539
1354-750X
1366-5804
https://nagoya.repo.nii.ac.jp/record/26866/files/Ohgami_re-revised_manuscript.pdf
eng
https://doi.org/10.1080/1354750X.2018.1458153
This is an Accepted Manuscript of an article published by Taylor & Francis Group in Biomarkers on 10/04/2018, available online: http://www.tandfonline.com/10.1080/1354750X.2018.1458153.