2024-03-28T16:13:00Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00027026
2023-11-16T04:20:36Z
499:508:509:2328
Clinical T staging is superior to fluorodeoxyglucose positron emission tomography for predicting local outcomes after intra-arterial infusion chemoradiotherapy for maxillary sinus squamous cell carcinoma
Doi, Hiroshi
88529
Fujiwara, Masayuki
88530
Kitajima, Kazuhiro
88531
Tanooka, Masao
88532
Terada, Tomonori
88533
Noguchi, Kazuma
88534
Ishikura, Reiichi
88535
Kamikonya, Norihiko
88536
Yamakado, Koichiro
88537
concurrency
intensity-modulated radiation therapy
paranasal sinus
intra-arterial infusion chemotherapy
maxillary sinus
radiotherapy
2018-11
Concomitant intra-arterial infusion chemoradiotherapy (IA-CRT) has been used to treat locally advanced maxillary sinus squamous cell carcinoma (MSSCC) with positive outcomes. However, an optimal predictive prognostic factor for MSSCC treated with IA-CRT remains elusive. The aim of the present study was to assess the feasibility of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET), including volumetric parameters, to predict the prognosis of MSSCC treated with IA-CRT. Twenty-four patients with newly diagnosed MSSCC receiving FDG-PET imaging before IA-CRT treatment were analyzed in this retrospective study. All patients underwent radiotherapy with a total tumor dose of 60–66 Gy in a conventional fractionation schedule, using three-dimensional conformal radiation therapy or intensitymodulated radiation therapy. Radiotherapy was performed concurrently with concurrent intra-arterial infusion chemotherapy (cisplatin). The IA-CRT response rate was 83.33%. The 1- and 3-year survival rates were 81.30% and 64.34%, respectively. The 1- and 3-year local failure-free rates were 57.21% and 40.96%, respectively. Local failure was significantly associated with poor survival (P = 0.0152). Further, clinical T staging clearly stratified local control outcomes among patients with clinical T3 or less, T4a, and T4b (P = 0.0312). Moreover, patients with stage T4b showed a significantly poorer local control compared with T3 or less (P = 0.0103). However, FDG-PET parameters provided no significant predictive information regarding treatment outcome. To conclude, pretreatment T stage predicts local control by IA-CRT, which is associated with survival.
This work was supported by a Grant-in-Aid for Young Scientists (B) Grant Number 17K16493.
departmental bulletin paper
Nagoya University Graduate School of Medicine, School of Medicine
2018-11
Nagoya Journal of Medical Science
4
80
541
550
2186-3326
0027-7622
eng
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/804.html
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International