2024-03-29T07:20:04Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00027068
2023-01-16T04:17:49Z
499:500:501
Neuroanatomical correlates of error types on the Clock Drawing Test in Alzheimer's disease patients
Nakashima, Hirotaka
88706
Umegaki, Hiroyuki
88707
Makino, Taeko
88708
Kato, Katsuhiko
88709
Abe, Shinji
88710
Suzuki, Yusuke
88711
Kuzuya, Masahumi
88712
dementia
executive function
functional neuroimaging
single‐photon emission computed tomography
spatial ability
Aim: We sought to identify the relationship between regional cerebral blood flow (rCBF) and error types on the Clock Drawing Test (CDT) in patients with Alzheimer's disease (AD). Method: The CDT was administered to 142 patients with AD. We used the Mendez scoring method. Their rCBF values were measured by single‐photon emission computed tomography. The correlation between the CDT total score and rCBF was examined on a voxel‐by‐voxel basis. After we excluded 37 patients whose drawings were inappropriate for assessing the CDT error types, we examined the relationships between each error type on the CDT and rCBF. Results: Total score on the CDT was positively correlated with rCBF in the left posterior middle temporal lobe. We also found relationships between the error “non‐existence of number 2, or not pointing toward number 2” and the left frontal lobe; the error “uneven number spacing” and the bilateral frontal lobe; “deviation of the clock center” and the left frontal lobe; “missing numbers” and the right parietal lobe; “uneven number distance from edge” and the right parietal and the temporal lobes; “same length hands” and the bilateral temporal lobe; and “unclosed circle” and the left temporal lobe. Conclusions: Each error type on the CDT appears to relate to a different brain region. These findings will be useful in the understanding of CDT performances and the underlying neuropsychological pathology.
journal article
Wiley
2016-07
application/pdf
Geriatrics & Gerontology International
7
16
777
784
1444-1586
https://nagoya.repo.nii.ac.jp/record/27068/files/article.pdf
eng
https://doi.org/10.1111/ggi.12550
This is the peer reviewed version of the following article: [Nakashima, H., Umegaki, H., Makino, T., Kato, K., Abe, S., Suzuki, Y., and Kuzuya, M. (2016) Neuroanatomical correlates of error types on the Clock Drawing Test in Alzheimer's disease patients. Geriatrics & Gerontology International, 16: 777–784. doi: 10.1111/ggi.12550.], which has been published in final form at [https://doi.org/10.1111/ggi.12550]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.