2024-03-29T06:20:27Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00028462
2023-11-16T02:58:33Z
499:508:509:2431
Otological aspects of Fabry disease in patients with normal hearing
Wang, Fei
93179
Yamamoto, Hiroshi
93180
Yoshida, Tadao
93181
Sugimoto, Satofumi
93182
Teranishi, Masaaki
93183
Tsuboi, Kazuya
93184
Sone, Michihiko
93185
Fabry disease
normal hearing
pure tone audiometry
otoacoustic emission
2019-08
We investigated the otological aspects of Fabry disease (FD) in patients with normal hearing. Forty-one patients (21 men, 20 women) with bilaterally normal hearing were recruited, and their otological symptoms and hearing evaluations, which included pure tone audiometry (PTA) and distortion product otoacoustic emission (DPOAE), were investigated. Ten of the 21 male (47.6%) and eight of the 20 female (40.0%) patients had otological symptoms, of which tinnitus was the most frequent. Cardiac dysfunction was more frequently observed in female patients. The average thresholds on PTA were below 25 dB at all frequencies, but DPOAE amplitudes were significantly lower in female patients at some frequencies. Otological symptoms were frequently observed in patients with FD, despite their normal hearing levels on PTA. DPOAE might provide useful information regarding cochlear disturbances related to the disease.
departmental bulletin paper
Nagoya University Graduate School of Medicine, School of Medicine
2019-08
Nagoya Journal of Medical Science
3
81
469
475
2186-3326
0027-7622
eng
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/813.html
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International