2024-03-28T14:02:37Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00028729
2023-01-16T04:42:45Z
499:500:501
Effect of antidepressant treatment on plasma levels of neuroinflammation‐associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region
Miyauchi, Tomoya
94353
Tokura, Tatsuya
94354
Kimura, Hiroyuki
94355
Ito, Mikiko
94356
Umemura, Eri
94357
Sato (Boku), Aiji
94358
Nagashima, Wataru
94359
Tonoike, Takashi
94360
Yamamoto, Yasuko
94361
Saito, Kuniaki
94362
Kurita, Kenichi
94363
Ozaki, Norio
94364
atypical odontalgia
burning mouth syndrome
chemokines
cytokines
neuroinflammation
somatic symptom disorder with predominant pain
Objective: Burning mouth syndrome (BMS) and atypical odontalgia (AO) are examples of somatic symptom disorders with predominant pain around the orofacial region. Neuroinflammation is thought to play a role in the mechanisms, but few studies have been conducted. We aimed to better understand the role of neuroinflammation in the pathophysiology and treatment of BMS/AO. Methods: Plasma levels of 28 neuroinflammation‐related molecules were determined in 44 controls and 48 BMS/AO patients both pretreatment and 12‐week post‐treatment with duloxetine. Results: Baseline plasma levels of interleukin (IL)‐1β (p < .0001), IL‐1 receptor antagonist (p < .001), IL‐6 (p < .0001), macrophage inflammatory protein‐1β (p < .0001), and platelet‐derived growth factor‐bb (.04) were significantly higher in patients than in controls. Plasma levels of granulocyte macrophage colony stimulating factor were significantly higher in patients than in controls (p < .001) and decreased with treatment (.009). Plasma levels of eotaxin, monocyte chemoattractant protein‐1, and vascular endothelial growth factor decreased significantly with treatment (p < .001, .022, and .029, respectively). Conclusions: Inflammatory mechanisms may be involved in the pathophysiology and/or treatment response of somatic symptom disorders with predominant pain around the orofacial region.
ファイル公開:2020-07-01
journal article
Wiley
2019-07
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Human Psychopharmacology: Clinical and Experimental
4
34
e2698
0885-6222
https://nagoya.repo.nii.ac.jp/record/28729/files/20190315_draft revised.pdf
https://nagoya.repo.nii.ac.jp/record/28729/files/Figure 1.pdf
https://nagoya.repo.nii.ac.jp/record/28729/files/Figure 2.pdf
https://nagoya.repo.nii.ac.jp/record/28729/files/Figure 3.pdf
https://nagoya.repo.nii.ac.jp/record/28729/files/Figure 4.pdf
eng
https://doi.org/10.1002/hup.2698
This is the peer reviewed version of the following article: [ Miyauchi, T, Tokura, T, Kimura, H, et al. Effect of antidepressant treatment on plasma levels of neuroinflammation‐associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region. Hum Psychopharmacol Clin Exp. 2019; 34:e2698. https://doi.org/10.1002/hup.2698], which has been published in final form at [https://doi.org/10.1002/hup.2698]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.