2024-03-28T20:48:30Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00028742
2023-11-16T02:59:20Z
499:508:509:2445
Association between green tea intake and risk of cognitive decline, considering glycated hemoglobin level, in older Japanese adults: the NILS-LSA study
Shirai, Yoshiro
94454
Kuriki, Kiyonori
94455
Otsuka, Rei
94456
Kato, Yuki
94457
Nishita, Yukiko
94458
Tange, Chikako
94459
Tomida, Makiko
94460
Imai, Tomoko
94461
Ando, Fujiko
94462
Shimokata, Hiroshi
94463
green tea
HbA1c
blood glucose level
cognitive decline
epidemiology
2019-11
Positive and negative associations with risk of cognitive decline have been reported for glycated hemoglobin (HbA1c) level and green tea (GT) intake, respectively. This study aimed to assess whether the reduction in the risk of cognitive decline with GT intake depended on HbA1c level. The participants were aged ≥60 years at baseline in the cohort study, wherein examinations were conducted biennially from 2000 to 2012. Subjects (n=1,304) who had no cognitive decline during the first survey and who had participated in the follow-up survey at least once were included. The follow-up end point was the first screening time point for cognitive decline (Mini-Mental State Examination score <27) or the last survey participation. With reference to the Japanese Diabetes Society guideline, the cut-off points for HbA1c level were set at 5.6%, 6.0%, and 6.5%, and lower and higher groups were assigned for each cut-off point. In a multiple Cox proportional hazard model, an interaction between GT intake and HbA1c groups for cognitive decline was observed only at HbA1c 6.0% (P-value for interaction [with Bonferroni’s correction] <0.05/3). Lower risks of cognitive decline were found for the HbA1c ≥5.6%, ≥6.0%, and <6.5% groups (hazard ratios: 0.59, 0.34, and 0.77; 95% confidence intervals: 0.41–0.88, 0.19–0.61, and 0.56–1.08 for “≥4 times a day” vs. “<once a day” GT intake, respectively; P-value for trend: 0.06, <0.01, and 0.09, respectively). With respect to blood glucose level, our cohort study showed non-uniformly reduced risk of cognitive decline with GT intake among older Japanese adults.
This study was also supported in part by JSPS KAKENHI (grant number: 15H02524).
departmental bulletin paper
Nagoya University Graduate School of Medicine, School of Medicine
2019-11
Nagoya Journal of Medical Science
4
81
655
666
2186-3326
0027-7622
eng
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/814.html
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