2024-03-29T06:02:03Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00028882
2023-01-16T04:30:25Z
2081:2082:2083
Potential of cryo-EM for high-resolution structural analysis of gap junction channels
Oshima, Atsunori
95022
Gap junction family proteins form conduits connecting the cytoplasm of adjacent cells, thereby enabling electrical and chemical coupling to maintain physiological homeostasis. Gap junction proteins comprise two gene families, connexins in chordates and innexins in pre-chordates. Their channel structures have been analyzed by electron or X-ray crystallography, but only a few atomic structures have been reported. Recent advances in single-particle cryo-electron microscopy (cryo-EM) will help to elucidate these structures further. Here the structural biology of gap junction channels utilizing crystallography and single-particle cryo-EM is overviewed to shed light on the functional mechanisms of cell–cell communication that are essential for multicellular organisms.
ファイル公開:2020-02-01
journal article
Elsevier
2019-02
application/pdf
Current Opinion in Structural Biology
54
78
85
0959-440X
https://nagoya.repo.nii.ac.jp/record/28882/files/Oshima_COSTB.pdf
eng
https://doi.org/10.1016/j.sbi.2019.01.005
© 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/