2024-03-29T13:24:30Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00030080
2023-11-16T03:00:19Z
499:508:509:2504
How to improve outcomes of elderly patients with acute myeloid leukemia: era of excitement
Naoe, Tomoki
99231
elderly patients
acute myeloid leukemia
chemotherapy
molecule-targeted drug
prognosis
2020-05
Among elderly patients with acute myeloid leukemia (AML), especially those who are unfit for intensive chemotherapy, a policy of reduced-intensity chemotherapy or conservative observation has been chosen, resulting in unmet medical needs. Clinical trials using anticancer drugs including antimetabolites or drugs targeted to cell cycle-related molecules failed to show superiority over conventional treatments. Recently, drugs targeted to Bcl-2, SMO, FLT3, and IDH1/2 have been shown to prolong overall survival alone or in combination with reduced-intensity chemotherapy. These treatments are likely to reshape the therapeutic landscape of AML, which will be personalized for individual patients based on leukemia genetics.
departmental bulletin paper
Nagoya University Graduate School of Medicine, School of Medicine
2020-05
Nagoya Journal of Medical Science
2
82
151
160
2186-3326
0027-7622
eng
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/822.html
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