2024-03-28T08:47:11Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00030534
2023-01-16T04:24:05Z
320:321:322
Pivotal Role of Interdigitation in Interleaflet Interactions: Implications from Molecular Dynamics Simulations
Seo, Sangjae
101620
Murata, Michio
101621
Shinoda, Wataru
101622
Lipids
Membranes
Phase separation
Acyls
Order
The asymmetric lipid composition in plasma membranes within the inner leaflet is not typically suitable for domain formation. Thus elucidation of the likelihood of the formation or stability of a raft-like domain in the inner leaflet is necessary. Herein we investigated the phase behavior of asymmetric membranes using coarse-grained molecular dynamics simulations. The lipid leaflet comprising dioleoylphosphatidylcholine (DOPC) and cholesterol (Chol) does not typically show well-developed domains in symmetric bilayer membranes; however, it does separate into liquid ordered (Lo) and liquid disordered (Ld) phases when the opposing leaflet containing sphingomyelin (SM), DOPC, and Chol demonstrates domain formation. We determine that interdigitated acyl chains modulated the partitioning of Chol in the opposing leaflet, resulting in phase separation. Similarly, the acyl chain length of SM within the opposing leaflet affected the phase behavior of the leaflet. Our results reveal the crucial role of interdigitation in determining the phase status in asymmetric membranes.
ファイル公開:2021-07-02
journal article
ACS Publications
2020-07-02
application/pdf
The Journal of Physical Chemistry Letters
13
11
5171
5176
1948-7185
https://nagoya.repo.nii.ac.jp/record/30534/files/JPCL2020.pdf
eng
https://doi.org/10.1021/acs.jpclett.0c01317
“This document is the Accepted Manuscript version of a Published Work that appeared in final form in [The Journal of Physical Chemistry Letters], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [https://pubs.acs.org/articlesonrequest/AOR-T9V5KKNRQCGKTINEMHX8].”