2024-03-28T19:41:00Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00030977
2023-11-16T02:45:01Z
499:508:509:2601
Assessment of the association between the polymorphism rs1256031 of the estrogen receptor β gene and GDM susceptibility
Li, Xi
102422
Su, Jindi
102423
Zheng, Kaifeng
102424
Lin, Sheng
102425
Chen, Shiguo
102426
Wang, Baojiang
102427
Lai, Liping
102428
Duan, Shan
102429
gestational diabetes mellitus
estrogen receptor β
single nucleotide polymorphism
2020-11
Estrogen has an important role in regulating glucose homeostasis, and existing evidence indicates that it might be involved in the development of hyperglycemia in pregnancy. It mediates its effect through estrogen receptors including the nuclear receptor ERβ encoded by ESR2. The association between the ESR2 polymorphism rs1256031 and GDM susceptibility has not been investigated yet. This study aimed to evaluate the relationship between rs1256031 and GDM risk in Chinese population. A total of 241 GDM patients and 139 healthy pregnant women were recruited for this study. The rs1256031 genotype was examined by time-of-flight mass spectrometry and the association between rs1256031 and GDM susceptibility was assessed by binary logistic regression in three different genetic models. The polymorphism rs1256031 was not associated with GDM susceptibility in additive [OR (95% CI) = 0.871 (0.453,1.675); P = 0.680], dominant [OR (95% CI) = 0.908 (0.495,1.665); P = 0.755] or recessive [OR (95% CI) = 0.912 (0.591,1.408); P = 0.677] models after adjusting for confounding factors. We observed no association between the polymorphism rs1256031 in the ESR2 gene and GDM susceptibility in Chinese pregnant women.
departmental bulletin paper
Nagoya University Graduate School of Medicine, School of Medicine
2020-11
Nagoya Journal of Medical Science
4
82
703
709
2186-3326
0027-7622
eng
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/824.html
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