2024-03-28T18:42:19Z
https://nagoya.repo.nii.ac.jp/oai
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2023-01-16T04:24:55Z
1903:1904:1905
Sulfur depletion induces autophagy through Ecl1 family genes in fission yeast
Shimasaki, Takafumi
103487
Okamoto, Keisuke
103488
Ohtsuka, Hokuto
103489
Aiba, Hirofumi
103490
autophagy
chronological lifespan
Ecl1 family genes
Schizosaccharomyces pombe
sulfur depletion
Autophagy is an intracellular degradation system widely conserved among various species. Autophagy is induced by the depletion of various nutrients, and this degradation mechanism is essential for adaptation to such conditions. In this study, we demonstrated that sulfur depletion induces autophagy in the fission yeast Schizosaccharomyces pombe. Based on the finding that autophagy induced by sulfur depletion was completely abolished in a mutant in which the ecl1, ecl2 and ecl3 genes were deleted (Δecls), we report that these three genes are essential for the induction of autophagy by sulfur depletion. Furthermore, autophagy‐defective mutant cells exhibited poor growth and short lifespan (compared with wild‐type cells) under the sulfur‐depleted condition. These results indicated that the mechanism of autophagy is necessary for the appropriate adaptation to sulfur depletion.
ファイル公開:2021-12-01
journal article
Wiley
2020-12
application/pdf
Genes to Cells
12
25
825
830
1356-9597
https://nagoya.repo.nii.ac.jp/record/31341/files/GENES_TO_CELLS_25_12_2020_825-830.pdf
eng
https://doi.org/10.1111/gtc.12815
This is the peer reviewed version of the following article: [Shimasaki, T, Okamoto, K, Ohtsuka, H, Aiba, H. Sulfur depletion induces autophagy through Ecl1 family genes in fission yeast. Genes Cells. 2020; 25: 825–830. https://doi.org/10.1111/gtc.12815], which has been published in final form at [https://doi.org/10.1111/gtc.12815]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.