2024-03-28T14:27:48Z
https://nagoya.repo.nii.ac.jp/oai
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2023-01-16T04:24:59Z
499:500:501
High levels of boron promote anchorage-independent growth of nontumorigenic cells
Xu, Huadong
103673
Hashimoto, Kazunori
103674
Maeda, Masao
103675
Azimi, Mohammad Daud
103676
Fayaz, Said Hafizullah
103677
Chen, Wei
103678
Hamajima, Nobuyuki
103679
Kato, Masashi
103680
Boron
Well drinking water
Tumorigenic risk
Tumorigenic pathway
WHO has presented a health-based guideline value for boron in drinking water. That fact indicates that a high level of boron is toxic for humans. However, there is no direct evidence of boron-mediated malignant transformation. In this study, human lung epithelial nontumorigenic BEAS-2B cells and tumorigenic A549 cells were used to investigate the tumorigenic toxicity of boron in vitro. Anchorage-independent growth, a hallmark of malignant transformation, was increased by boron at concentrations of 50, 250 and 500 μM in BEAS-2B cells, though the same concentrations of boron had no influence on anchorage-independent growth of A549 cells. Moreover, boron at concentrations of 250 and 500 μM activated the c-SRC/PI3K/AKT pathway of BEAS-2B cells. The results of our in vitro study suggest that exposure to high levels of boron promotes transforming activity of nontumorigenic cells.
ファイル公開:2022-11-01
journal article
Elsevier
2020-11
application/pdf
Environmental Pollution
266
115094
0269-7491
https://nagoya.repo.nii.ac.jp/record/31433/files/ENVIRONMENTAL_POLLUTION_2020_266_115094.pdf
eng
https://doi.org/10.1016/j.envpol.2020.115094
© 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/