2024-03-28T09:24:32Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:02001581
2023-01-16T05:16:35Z
1903:1904:1905
Synthesis of difluoromethylated diarylmethanes via Fe(OTf)3-catalyzed Friedel–Crafts reaction of 2,2-difluoro-1-arylethyl phosphates
Yamamoto, Yoshihiko
Takase, Tomoya
Kuroyanagi, Eisuke
Yasui, Takeshi
The Fe(OTf)3-catalyzed Friedel–Crafts reaction of 2,2-difluoro-1-arylethyl phosphates with electron-rich (hetero)arenes afforded difluoromethylated diarylmethanes. Control experiments showed that Fe(OTf)3 behaves as the Lewis acid, and that the phosphate leaving group and o- or p-alkoxy substituents on the substrates are necessary for the Fe(OTf)3-catalyzed reaction to proceed under mild conditions.
journal article
Royal Society of Chemistry
2021-04-25
application/pdf
Chemical Communications
32
57
3877
3880
1359-7345
https://nagoya.repo.nii.ac.jp/record/2001581/files/CC_MS_rev2.pdf
eng
https://doi.org/10.1039/D1CC00765C