2024-03-29T09:51:02Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:02001897
2023-01-16T04:39:59Z
1903:1904:1905
Identification of sur2 mutation affecting the lifespan of fission yeast
Kurauchi, Tatsuhiro
Matsui, Kotaro
Shimasaki, Takafumi
Ohtsuka, Hokuto
Tsubouchi, Satoshi
Ihara, Kunio
Tani, Motohiro
Aiba, Hirofumi
lifespan
Schizosaccharomyces pombe
aging
sphingolipid hydroxylase
Sur2
yeast
Yeast is a suitable model system to analyze the mechanism of lifespan. In this study, to identify novel factors involved in chronological lifespan, we isolated a mutant with a long chronological lifespan and found a missense mutation in the sur2^+ gene, which encodes a homolog of Saccharomyces cerevisiae sphingolipid C4-hydroxylase in fission yeast. Characterization of the mutant revealed that loss of sur2 function resulted in an extended chronological lifespan. The effect of caloric restriction, a well-known signal for extending lifespan, is thought to be dependent on the sur2^+ gene.
journal article
Oxford University Press
2021-06-10
application/pdf
FEMS Microbiology Letters
12
368
fnab070
0378-1097
https://nagoya.repo.nii.ac.jp/record/2001897/files/fnab070.pdf
eng
https://doi.org/10.1093/femsle/fnab070
This is a pre-copyedited, author-produced version of an article accepted for publication in [FEMS Microbiology Letters] following peer review. The version of record [Tatsuhiro Kurauchi, Kotaro Matsui, Takafumi Shimasaki, Hokuto Ohtsuka, Satoshi Tsubouchi, Kunio Ihara, Motohiro Tani, Hirofumi Aiba, Identification of sur2 mutation affecting the lifespan of fission yeast, FEMS Microbiology Letters, Volume 368, Issue 12, June 2021, fnab070, https://doi.org/10.1093/femsle/fnab070] is available online at: https://doi.org/10.1093/femsle/fnab070.