2024-03-29T05:15:27Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:02002129
2023-11-16T01:57:41Z
499:508:509:1646019880489
The equilibrated blood sevoflurane concentrations show a rapid decrease after switching from ventilation for the human lung to cardiopulmonary bypass
Tamura, Takahiro
Mori, Atsushi
Ishii, Akira
Nishiwaki, Kimitoshi
cardiopulmonary bypass
sevoflurane
blood concentration
oxygenator
human lung ventilation
Volatile anesthetics (VAs) protect myocardial cells during cardiovascular surgeries, including cardiopulmonary bypass (CPB). In CPB, blood is gradually transferred from the body to a CPB unit until the target cardiac index is achieved, following which human lung (HL) ventilation is stopped. This pilot study aimed to evaluate changes in the blood sevoflurane concentrations 5 min after the start of CPB when its delivery to the oxygenator began after HL ventilation with sevoflurane was completed. Six patients were recruited and participated in this study. For each patient, the equilibrated blood sample, collected 20 min after starting the delivery of 1.7% sevoflurane (HL group), and another blood sample, collected 5 min after starting the CPB, were analyzed using gas chromatography equipped with a flame ionization detector. The mean (± standard deviation) sevoflurane concentrations in the HL and 5 min after starting CPB groups were 58.6 ± 4.7 and 14.5 ± 5.0 μg/ml, respectively (P < 0.01). In conclusion, the equilibrated blood sevoflurane concentrations showed a rapid decrease when switching from sevoflurane ventilation for the HL to CPB unless it was introduced to the oxygenator until completion of the switch.
departmental bulletin paper
Nagoya University Graduate School of Medicine, School of Medicine
2022-02
application/pdf
Nagoya Journal of Medical Science
1
84
163
168
0027-7622
2186-3326
https://nagoya.repo.nii.ac.jp/record/2002129/files/17_Tamura.pdf
eng
https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/841.html
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