2024-03-28T15:49:32Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:02005199
2023-03-27T02:21:58Z
1213:1620:1621:1679636128616
Single nucleotide polymorphisms (SNPs) in ATP synthase subunit 8 and 6 genes of mitochondrial DNA in elite distance runners
エリート陸上競技長距離走者におけるミトコンドリアATP8/6遺伝子の一塩基多型
武安, 岳史
TAKEYASU, Takeshi
押田, 芳治
OSHIDA, Yoshiharu
福, 典之
FUKU, Noriyuki
宮田, 浩文
MIYATA, Hirofumi
田中, 雅嗣
TANAKA, Masashi
佐藤, 祐造
SATO, Yuzo
The purpose of this study was to identify single nucleotide polymorphisms (SNPs) of mitochondrial DNA (mtDNA) in elite distance runners. We sequenced the two genes (ATP6 and ATP8) of ATP synthase and compared the frequencies of nucleotide variants among elite endurance runners (n=10), non-elite endurance runners (n=50), elite sprinters (n=3), other athletes (n=25), and healthy untrained individuals (controls; n=21). The frequency of Mt8414C→T (Leul7Phe in ATP8) was lower in the elite runners (30%) than in the controls (57%), but the difference was not significant. In contrast, the higher frequency of Mt8563A→G (Thrl3Ala in ATP6) was observed in the elite runners (30%) than in other groups (non-elite runners; 2%, elite sprinters; 0%, other athletes; 12%, and controls; 5%). There was a significant difference between the elite runners and the non-elite runners (p<0.05). The elite runners had a lower frequency of Mt8701A→G (Thr59Ala in ATP6) (40%) than controls (71%), although the difference was not significant. Significantly higher frequency of Mt8794C→T (His90Tyr in ATP6) was found in the elite runners (50%) than in other groups (non-elite runners, 8%; other athletes, 12%; and controls, 5%). These results suggest that Mt8794T is related to high performance in endurance running.
departmental bulletin paper
名古屋大学総合保健体育科学センター
The Research Center of Health, Physical Fitness and Sports, Nagoya University
2002-03-29
application/pdf
総合保健体育科学
1
25
19
22
Nagoya Journal of Health, Physical Fitness & Sports
0289-5412
https://nagoya.repo.nii.ac.jp/record/2005199/files/njhpfs_25_1_19.pdf
jpn