2024-03-29T07:31:44Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:02005217
2023-03-29T00:39:03Z
1213:1620:1621:1679893093947
Effects of CO2 inhalation on glucose tolerance in STZ-induced diabetic rats
高CO2吸入が糖負荷後の血糖値に及ぼす影響
福, 典之
FUKU, Noriyuki
押田, 芳治
OSHIDA, Yoshiharu
韓, 艶清
HAN, Yanqing
越中, 敬一
KOSHINAKA, Keiichi
佐藤, 祐造
SATO, Yuzo
The present study was undertaken to examine the effects of high CO2 inhalation on the glucose tolerance in STZ-induced diabetic rats using an oral glucose tolerance test (OGTT). In the "room air group" experiment: after a 18 h fast, glucose (2 g/kg body weight) was administered under room air condition. Blood samples were obtained at rest before glucose administration, and at 30 min intervals during the 120 min OGTT to measure blood glucose and serum insulin concentrations. In the "high CO2 group" experiment: the rats inhaled 5 % CO2 and 21% O2 for 60 min after glucose administration. The experimental protocol was the same as "room air group". During an OGTT, the blood glucose concentrations were significantly lower in high CO2 group than in room air group (60 min: 251 ± 13 vs. 325 ± 24 mg/dl, p< 0.001, 90min: 229 ± 15 vs. 313 ± 15 mg/dl, p<0.001, 120 min: 219 ± 25 vs. 313 ± 25 mg/di, p<0.01). Changes in serum insulin concentration in both groups were not found after glucose load. In conclusion, high CO2 inhalation after glucose administration caused a decrease in blood glucose concentration with no change in serum insulin concentration.
departmental bulletin paper
名古屋大学総合保健体育科学センター
The Research Center of Health, Physical Fitness and Sports, Nagoya University
2001-03-31
application/pdf
総合保健体育科学
1
24
25
28
Nagoya Journal of Health, Physical Fitness & Sports
0289-5412
https://nagoya.repo.nii.ac.jp/record/2005217/files/njhpfs_24_1_25.pdf
jpn