2024-03-28T14:17:29Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:02005492
2023-04-18T00:16:30Z
1213:1620:1621:1681451207591
Ketone body metabolism in muscle (III) : Changes in keton body concentration in the 12 Hz-stimulated muscle
骨格筋におけるケトン体代謝に関する研究(第3報) : 12Hz刺激による連動筋でのケトン体変動
楊, 衛平
YANG, Wei-Ping
押田, 芳治
OSHIDA, Yoshiharu
呉, 瑋
WU, Wei
佐藤, 寿一
SATO, Juichi
大沢, 功
OHSAWA, Isao
佐藤, 祐造
SATO, Yuzo
Physical training has been shown to improve insulin action in simple obese and obese diabetic patients. On the other hand,the hyperketonemic effect of prolonged exercise in insulin-dependent diabetic patients is well recognized phenomenon. Recently, we have demonstrated that 60-min high-frequency (60Hz) stimulation produces a significant reduction in 3-hydroxybutyrate (3-OHBA) uptake in muscle not only in diabetic but also in control rats and that a reduction in 3-OHBA utilization in diabetics is found for 90 min after muscle constriction. In the present study. we measured extracellular 3-OHBA concentrations in 12Hz-stimulated muscle for five diabetic and five control rats by use of the microdialysis technique. The following results were obtained: 1. In control rats, there was no significant difference in 3-OHBA levels between before, during and after stimulation. 2. In diabetics, the dialysate 3-OHBA concentrations showed a significant increase during constriction and for 90 min after constriction. It is well known that 12Hz-stimuli is more aerobic in muscle than 60-Hz-stimuli. Therefore, it may be advisable that diabetic patients performe an aerobic exercise, in order to increase insulin action in peripheral tissue, after nearly normalization for metabolism by diet and insulin therapy, and so on.
departmental bulletin paper
名古屋大学総合保健体育科学センター
The Research Center of Health, Physical Fitness and Sports, Nagoya University
1994-03-30
application/pdf
総合保健体育科学
1
17
13
16
Nagoya Journal of Health, Physical Fitness & Sports
0289-5412
https://nagoya.repo.nii.ac.jp/record/2005492/files/njhpfs_17_1_13.pdf
jpn