2024-03-28T16:03:53Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:02005514
2023-04-19T04:22:16Z
1213:1620:1621:1681709824988
Ketone body metabolism in muscle (II) : Changes in acetoacetate concentration in constricted muscle
骨格筋におけるケトン体代謝に関する研究(第2報) : 運動筋におけるアセト酢酸の代謝変動
呉, 瑋
WU, Wei
押田, 芳治
OSHIDA, Yoshiharu
楊, 衛平
YANG, Wei-Ping
佐藤, 寿一
SATO, Juichi
大沢, 功
OHSAWA, Isao
佐藤, 祐造
SATO, Yuzo
Physical training has been shown to improve insulin action in simple obese and diabetic patients. On the other hand, the hyperketonemic effect of prolonged exercise in insulin-dependent diabetic patients is a well recognized phenomenon. Therefore, in order to evaluate the mechanism, especially the effect of exercise in ketone body metabolism m muscle, we measured extracellular acetoacetate (AcAc) concentrations in muscle of five diabetic and five control rats. The following results were obtained; 1. In control rats, constriction produced a significant rise in dialysate AcAc concentration which rapidly returned to pre-constriction levels after constriction. 2. In diabetics, the dialysate AcAc concentrations showed a significant increase during constriction and for 60 min after constriction. These results suggest that exercise results in a significant reduction in ketone body utilization in muscle not only in diabetic but also control rats and a reduction in ketone body utilization after muscle constriction in poorly-controlled diabetics plays a role in post-exercise hyperketonemia.
departmental bulletin paper
名古屋大学総合保健体育科学センター
The Research Center of Health, Physical Fitness and Sports, Nagoya University
1993-03-30
application/pdf
総合保健体育科学
1
16
13
17
Nagoya Journal of Health, Physical Fitness & Sports
0289-5412
https://nagoya.repo.nii.ac.jp/record/2005514/files/njhpfs_16_1_13.pdf
jpn