{"created":"2021-03-01T06:17:21.433551+00:00","id":10524,"links":{},"metadata":{"_buckets":{"deposit":"804d71a7-acf0-4e20-bd34-06ec57bc8335"},"_deposit":{"created_by":17,"id":"10524","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"10524"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00010524","sets":["499:508:509:1171"]},"author_link":["31876","31877","31878","31879","31880"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"114","bibliographicPageStart":"109","bibliographicVolumeNumber":"71","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A target of NESH-SH3/Abi3bp (TARSH) was originally identified as an SH3 domain-binding molecule of the NESH-SH3/Abi3 protein that is involved in Rac-dependent actin polymerization. In recent studies, TARSH gene expression was dramatically induced in mouse embryonic fibroblasts (MEFs) replicative senescence and suppressed in human lung carcinoma specimens and thyroid carcinomas. However, the molecular mechanism underlying the regulation of TARSH in tumorigenesis remains unclear. Here, we address a p53-dependent apoptosis function of the mouse TARSH gene using RNAi-mediated suppression of endogenous TARSH expression. Our results will be useful in the discovery of a novel therapeutic\ntarget in lung carcinoma.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/12347"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.71.3-4.109","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University School of Medicine","subitem_publisher_language":"en"}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_61":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"}]},"item_9_text_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_text_value":"application/pdf"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"WAKOH, TAKESHI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"31876","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SUGIMOTO, MASATAKA","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"31877","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TERAUCHI, KUNIHIKO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"31878","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SHIMADA, JUN-ICHI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"31879","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MARUYAMA, MITSUO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"31880","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-20"}],"displaytype":"detail","filename":"p109-114_Wakoh.pdf","filesize":[{"value":"244.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"p109-114_Wakoh.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/10524/files/p109-114_Wakoh.pdf"},"version_id":"b703dadd-7599-4f73-9b45-d42ff840be4f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cell cycle","subitem_subject_scheme":"Other"},{"subitem_subject":"Apoptosis","subitem_subject_scheme":"Other"},{"subitem_subject":"Tumor suppression","subitem_subject_scheme":"Other"},{"subitem_subject":"TARSH","subitem_subject_scheme":"Other"},{"subitem_subject":"p53","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A NOVEL P53-DEPENDENT APOPTOSIS FUNCTION OF TARSH IN TUMOR DEVELOPMENT","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A NOVEL P53-DEPENDENT APOPTOSIS FUNCTION OF TARSH IN TUMOR DEVELOPMENT","subitem_title_language":"en"}]},"item_type_id":"9","owner":"17","path":["1171"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-11-30"},"publish_date":"2009-11-30","publish_status":"0","recid":"10524","relation_version_is_last":true,"title":["A NOVEL P53-DEPENDENT APOPTOSIS FUNCTION OF TARSH IN TUMOR DEVELOPMENT"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-11-16T06:35:08.553144+00:00"}