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INTERLEUKIN-8 T-251A POLYMORPHISM WAS ASSOCIATED WITH POSITIVE ANTI-p53 ANTIBODIES IN UZBEKISTAN POPULATION
https://doi.org/10.18999/nagjms.71.3-4.151
https://doi.org/10.18999/nagjms.71.3-4.151209a43b7-829f-444f-9f2d-c4d82208598c
名前 / ファイル | ライセンス | アクション |
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p151-156_Okada.pdf (93.0 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2009-11-30 | |||||
タイトル | ||||||
タイトル | INTERLEUKIN-8 T-251A POLYMORPHISM WAS ASSOCIATED WITH POSITIVE ANTI-p53 ANTIBODIES IN UZBEKISTAN POPULATION | |||||
言語 | en | |||||
著者 |
OKADA, RIEKO
× OKADA, RIEKO× RAHIMOV, BAKHODIR× AHN, KEUN SOO× ABDIEV, SHAVKAT× MALIKOV, YUSUF× BAHRAMOV, SAIDKARIM× NAITO, MARIKO× HAMAJIMA, NOBUYUKI |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Interleukin-8 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Anti-p53 antibody | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Genetic polymorphism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Uzbekistan | |||||
抄録 | ||||||
内容記述 | Interleukin (IL)-8, a proinflammatory chemokine, has been reported to have angiogenic activity and to be responsible for tumor-associated angiogenesis in several cancers. The polymorphism IL-8 T-251A (rs4073) is known to be associated with the expression of IL-8 protein and is related to several cancers. A serum anti-p53 antibody, a new tumor marker, increases in accordance with the mutation of tumor suppressor gene p53. Previous studies have reported the association between IL-8 and p53 mutation in cancer cells or tissues. Therefore, we hypothesized that IL-8 polymorphism might be associated with serum anti-p53 antibody levels. Study subjects were 197 participants (103 males and 94 females, aged 15 to 56 years) who were enrolled in a case-control study on peptic ulcer disease from January to March 2007 in the Uzbekistan Republic. Serum anti-p53 antibody, CEA, and CA19-9 levels were measured, and IL-8 T-251A was genotyped. The A allele frequency in control subjects was 0.48, which is close to the previous reports for Caucasian populations. The proportion of subjects with positive anti-p53 antibodies (higher than 1.3 U/mL) was greater for AA genotype carriers compared to T allele carriers (17% for AA, and 6% for TA+TT; OR 3.4, p = 0.025 after adjusting for age, sex, comorbidity and ethnicity). Such a difference was not observed for either CEA or CA19-9. We demonstrated that the IL-8 -251 AA genotype was associated with higher anti-p53 antibodies than those of the reference range. Further studies are warranted to clarify whether those with this genotype carrier are susceptible to malignant diseases. |
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言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Nagoya University School of Medicine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.71.3-4.151 | |||||
ID登録タイプ | JaLC | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0027-7622 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2186-3326 | |||||
書誌情報 |
en : Nagoya Journal of Medical Science 巻 71, 号 3-4, p. 151-156, 発行日 2009-09 |
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フォーマット | ||||||
application/pdf | ||||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/12351 | |||||
識別子タイプ | HDL |