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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 71(3-4)

INTERLEUKIN-8 T-251A POLYMORPHISM WAS ASSOCIATED WITH POSITIVE ANTI-p53 ANTIBODIES IN UZBEKISTAN POPULATION

https://doi.org/10.18999/nagjms.71.3-4.151
https://doi.org/10.18999/nagjms.71.3-4.151
209a43b7-829f-444f-9f2d-c4d82208598c
名前 / ファイル ライセンス アクション
p151-156_Okada.pdf p151-156_Okada.pdf (93.0 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2009-11-30
タイトル
タイトル INTERLEUKIN-8 T-251A POLYMORPHISM WAS ASSOCIATED WITH POSITIVE ANTI-p53 ANTIBODIES IN UZBEKISTAN POPULATION
著者 OKADA, RIEKO

× OKADA, RIEKO

WEKO 31920

OKADA, RIEKO

Search repository
RAHIMOV, BAKHODIR

× RAHIMOV, BAKHODIR

WEKO 31921

RAHIMOV, BAKHODIR

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AHN, KEUN SOO

× AHN, KEUN SOO

WEKO 31922

AHN, KEUN SOO

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ABDIEV, SHAVKAT

× ABDIEV, SHAVKAT

WEKO 31923

ABDIEV, SHAVKAT

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MALIKOV, YUSUF

× MALIKOV, YUSUF

WEKO 31924

MALIKOV, YUSUF

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BAHRAMOV, SAIDKARIM

× BAHRAMOV, SAIDKARIM

WEKO 31925

BAHRAMOV, SAIDKARIM

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NAITO, MARIKO

× NAITO, MARIKO

WEKO 31926

NAITO, MARIKO

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HAMAJIMA, NOBUYUKI

× HAMAJIMA, NOBUYUKI

WEKO 31927

HAMAJIMA, NOBUYUKI

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キーワード
主題Scheme Other
主題 Interleukin-8
キーワード
主題Scheme Other
主題 Anti-p53 antibody
キーワード
主題Scheme Other
主題 Genetic polymorphism
キーワード
主題Scheme Other
主題 Uzbekistan
抄録
内容記述 Interleukin (IL)-8, a proinflammatory chemokine, has been reported to have angiogenic activity and to be responsible for tumor-associated angiogenesis in several cancers. The polymorphism IL-8 T-251A (rs4073) is known to be associated with the expression of IL-8 protein and is related to several cancers. A serum anti-p53 antibody, a new tumor marker, increases in accordance with the mutation of tumor suppressor
gene p53. Previous studies have reported the association between IL-8 and p53 mutation in cancer cells or tissues. Therefore, we hypothesized that IL-8 polymorphism might be associated with serum anti-p53
antibody levels. Study subjects were 197 participants (103 males and 94 females, aged 15 to 56 years) who were enrolled in a case-control study on peptic ulcer disease from January to March 2007 in the Uzbekistan Republic. Serum anti-p53 antibody, CEA, and CA19-9 levels were measured, and IL-8 T-251A was genotyped. The A allele frequency in control subjects was 0.48, which is close to the previous reports for Caucasian populations. The proportion of subjects with positive anti-p53 antibodies (higher than 1.3 U/mL) was greater for AA genotype carriers compared to T allele carriers (17% for AA, and 6% for TA+TT; OR 3.4, p = 0.025 after adjusting for age, sex, comorbidity and ethnicity). Such a difference was not observed for either CEA or CA19-9. We demonstrated that the IL-8 -251 AA genotype was associated with higher anti-p53 antibodies than those of the reference range. Further studies are warranted to clarify
whether those with this genotype carrier are susceptible to malignant diseases.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.71.3-4.151
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 71, 号 3-4, p. 151-156, 発行日 2009-09
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/12351
識別子タイプ HDL
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