{"_buckets": {"deposit": "d2bd7719-e29b-4d92-b7ef-3be8f48f43b3"}, "_deposit": {"id": "10528", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "10528"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00010528"}, "item_9_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3-4", "bibliographicPageEnd": "156", "bibliographicPageStart": "151", "bibliographicVolumeNumber": "71", "bibliographic_titles": [{"bibliographic_title": "Nagoya Journal of Medical Science"}]}]}, "item_9_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Interleukin (IL)-8, a proinflammatory chemokine, has been reported to have angiogenic activity and to be responsible for tumor-associated angiogenesis in several cancers. The polymorphism IL-8 T-251A (rs4073) is known to be associated with the expression of IL-8 protein and is related to several cancers. A serum anti-p53 antibody, a new tumor marker, increases in accordance with the mutation of tumor suppressor\ngene p53. Previous studies have reported the association between IL-8 and p53 mutation in cancer cells or tissues. Therefore, we hypothesized that IL-8 polymorphism might be associated with serum anti-p53\nantibody levels. Study subjects were 197 participants (103 males and 94 females, aged 15 to 56 years) who were enrolled in a case-control study on peptic ulcer disease from January to March 2007 in the Uzbekistan Republic. Serum anti-p53 antibody, CEA, and CA19-9 levels were measured, and IL-8 T-251A was genotyped. The A allele frequency in control subjects was 0.48, which is close to the previous reports for Caucasian populations. The proportion of subjects with positive anti-p53 antibodies (higher than 1.3 U/mL) was greater for AA genotype carriers compared to T allele carriers (17% for AA, and 6% for TA+TT; OR 3.4, p = 0.025 after adjusting for age, sex, comorbidity and ethnicity). Such a difference was not observed for either CEA or CA19-9. We demonstrated that the IL-8 -251 AA genotype was associated with higher anti-p53 antibodies than those of the reference range. Further studies are warranted to clarify\nwhether those with this genotype carrier are susceptible to malignant diseases.", "subitem_description_type": "Abstract"}]}, "item_9_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/12351"}]}, "item_9_identifier_registration": {"attribute_name": "ID\u767b\u9332", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/nagjms.71.3-4.151", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Nagoya University School of Medicine"}]}, "item_9_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_9_source_id_7": {"attribute_name": "ISSN\uff08print\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "0027-7622", "subitem_source_identifier_type": "ISSN"}]}, "item_9_text_14": {"attribute_name": "\u30d5\u30a9\u30fc\u30de\u30c3\u30c8", "attribute_value_mlt": [{"subitem_text_value": "application/pdf"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "OKADA, RIEKO"}], "nameIdentifiers": [{"nameIdentifier": "31920", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "RAHIMOV, BAKHODIR"}], "nameIdentifiers": [{"nameIdentifier": "31921", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "AHN, KEUN SOO"}], "nameIdentifiers": [{"nameIdentifier": "31922", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ABDIEV, SHAVKAT"}], "nameIdentifiers": [{"nameIdentifier": "31923", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "MALIKOV, YUSUF"}], "nameIdentifiers": [{"nameIdentifier": "31924", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "BAHRAMOV, SAIDKARIM"}], "nameIdentifiers": [{"nameIdentifier": "31925", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "NAITO, MARIKO"}], "nameIdentifiers": [{"nameIdentifier": "31926", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "HAMAJIMA, NOBUYUKI"}], "nameIdentifiers": [{"nameIdentifier": "31927", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "p151-156_Okada.pdf", "filesize": [{"value": "93.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 93000.0, "url": {"label": "p151-156_Okada.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/10528/files/p151-156_Okada.pdf"}, "version_id": "4abd599a-94af-4921-b1c7-d2ef3c6908a7"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Interleukin-8", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Anti-p53 antibody", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Genetic polymorphism", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Uzbekistan", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "INTERLEUKIN-8 T-251A POLYMORPHISM WAS ASSOCIATED WITH POSITIVE ANTI-p53 ANTIBODIES IN UZBEKISTAN POPULATION", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "INTERLEUKIN-8 T-251A POLYMORPHISM WAS ASSOCIATED WITH POSITIVE ANTI-p53 ANTIBODIES IN UZBEKISTAN POPULATION"}]}, "item_type_id": "9", "owner": "1", "path": ["499/508/509/1171"], "permalink_uri": "https://doi.org/10.18999/nagjms.71.3-4.151", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2009-11-30"}, "publish_date": "2009-11-30", "publish_status": "0", "recid": "10528", "relation": {}, "relation_version_is_last": true, "title": ["INTERLEUKIN-8 T-251A POLYMORPHISM WAS ASSOCIATED WITH POSITIVE ANTI-p53 ANTIBODIES IN UZBEKISTAN POPULATION"], "weko_shared_id": null}