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C-ヌクレオシドの一般合成法
http://hdl.handle.net/2237/12410
http://hdl.handle.net/2237/124105183e6a2-1f25-46b7-afd3-6880c6190f5e
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ko1586.pdf (9.7 MB)
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ko1586_abstr.pdf (124.1 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2009-12-16 | |||||
タイトル | ||||||
タイトル | C-ヌクレオシドの一般合成法 | |||||
言語 | ja | |||||
その他のタイトル | ||||||
その他のタイトル | GENERAL SYNTHESIS OF C-NUCLEOSIDES | |||||
言語 | en | |||||
著者 |
佐藤, 恒夫
× 佐藤, 恒夫× Sato, Tsuneo |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述 | The stereocontrolled, general synthesis of C-nucleosides starting from inexpensive non-carbohydrate substances has been accomplished. Construction of' the ribose skeleton, a key operation,relies on the efficiency of the [3 + 4] cyclocoupling reaction between polybromo ketones and furans aided by low-valent transition metals which leads to 8-oxabicyclo[3.2.1]octan-3-one structures. Pseudouridine and its analogues such as 2-thiopseudouridine,pseudoisocytidine, 6-azapseudouridine, and 6-aza-2-thiopseudouridine have been synthesized from (1R,6S,7S,8R)-7,8-isopropylidenedioxy-3,9-dioxabicyclo[4.2.l^l,6]nonan-4-one. Showdomycin is also obtainable from the common intermediate. A variety of pyrimidine C-nucleosides bearing branched-chain sugars have been synthesized starting from adequately substituted (lR*,6S*,7S*,8R*)-7,8-isopropylidenedioxy-3,9- dioxabicyclo[4.2.1^1,6]nonan-4-ones in only three steps. In addition, the straightforward synthesis of homo-C-nucleosides has been achieved, which allows the synthesis of homopseudouridine, homoshowdomycin, homopyrazomycin, etc. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | 名古屋大学博士学位論文 学位の種類 : 理学博士(課程) 学位授与年月日 : 昭和58年4月30日 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_db06 | |||||
タイプ | doctoral thesis | |||||
書誌情報 |
発行日 1983-04-30 |
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学位名 | ||||||
言語 | ja | |||||
学位名 | 理学博士 | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 13901 | |||||
言語 | ja | |||||
学位授与機関名 | 名古屋大学 | |||||
言語 | en | |||||
学位授与機関名 | Nagoya University | |||||
学位授与年度 | ||||||
学位授与年度 | 1983 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 1983-04-30 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第1586号 | |||||
フォーマット | ||||||
application/pdf | ||||||
フォーマット | ||||||
application/pdf | ||||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/12410 | |||||
識別子タイプ | HDL |