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  1. B200 工学部/工学研究科
  2. B200a 雑誌掲載論文
  3. 学術雑誌

Multidimensional theory of protein folding

http://hdl.handle.net/2237/12626
http://hdl.handle.net/2237/12626
86956c49-f96b-4552-b6ef-ffc651435902
名前 / ファイル ライセンス アクション
JChemPhys_130_145104.pdf JChemPhys_130_145104.pdf (5.4 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2010-01-20
タイトル
タイトル Multidimensional theory of protein folding
言語 en
著者 Itoh, Kazuhito

× Itoh, Kazuhito

WEKO 32385

en Itoh, Kazuhito

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Sasai, Masaki

× Sasai, Masaki

WEKO 32386

en Sasai, Masaki

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 Copyright (2009) American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior per mission of the author and the American Institute of Physics.
キーワード
主題Scheme Other
主題 biochemistry
キーワード
主題Scheme Other
主題 free energy
キーワード
主題Scheme Other
主題 molecular biophysics
キーワード
主題Scheme Other
主題 molecular configurations
キーワード
主題Scheme Other
主題 proteins
抄録
内容記述 Theory of multidimensional representation of free energy surface of protein folding is developed byadopting structural order parameters of multiple regions in protein as multiple coordinates. Various scenarios of folding are classified in terms of cooperativity within individual regions and interactions among multiple regions and thus obtained classification is used to analyze the folding process of several example proteins. Ribosomal protein S6, src-SH3 domain, CheY, barnase, and BBL domain are analyzed with the two-dimensional representation by using a structure-based Hamiltonian model. The extension to the higher dimensional representation leads to the finer description of the folding process. Barnase, NtrC, and an ankyrin repeat protein are examined with the three-dimensional representation. The multidimensional representation allows us to directly address questions on folding pathways, intermediates, and transition states.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 American Institite of Physics
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1063/1.3097018
ISSN
収録物識別子タイプ PISSN
収録物識別子 0021-9606
書誌情報 en : THE JOURNAL OF CHEMICAL PHYSICS

巻 130, 号 4, p. 145104-145104, 発行日 2009-04-13
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/12626
識別子タイプ HDL
URI
識別子 http://dx.doi.org/10.1063/1.3097018
識別子タイプ DOI
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