{"created":"2021-03-01T06:17:54.705573+00:00","id":11042,"links":{},"metadata":{"_buckets":{"deposit":"d4ee68da-3bc0-4c1b-89a6-75fee23f0afe"},"_deposit":{"created_by":17,"id":"11042","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"11042"},"status":"published"},"_oai":{"id":"oai:nagoya.repo.nii.ac.jp:00011042","sets":["499:508:509:1196"]},"author_link":["33472"],"item_1615768549627":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_9_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"11","bibliographicPageStart":"1","bibliographicVolumeNumber":"72","bibliographic_titles":[{"bibliographic_title":"Nagoya Journal of Medical Science","bibliographic_titleLang":"en"}]}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Indoxyl sulfate, a uremic toxin, is accumulated in the serum of chronic kidney disease (CKD) patients.A part of the dietary protein-derived tryptophan is metabolized into indole by tryptophanase in intestinal bacteria. Indole is absorbed into the blood from the intestine, and is metabolized to indoxyl sulfate in the liver. Indoxyl sulfate is normally excreted into urine. In CKD, however, an inadequate renal clearance of\nindoxyl sulfate leads to its elevated serum levels. The oral adsorbent AST-120 reduces the serum levels of indoxyl sulfate by adsorbing indole in the intestines and stimulating its excretion into feces. I have proposed a protein metabolite theory by which endogenous protein metabolites such as indoxyl sulfate play a significant role in the progression of CKD. A progressive decline in the glomerular filtration rate leads to increased serum levels of endogenous protein metabolites such as indoxyl sulfate, and to the adverse effects of their overload on the remnant nephrons. Indoxyl sulfate stimulates progressive both tubulointerstitial fibrosis and glomerular sclerosis by increasing the expression of transforming growth factor-b1, a tissue inhibitor of metalloproteinase-1 and proa1 (I) collagen, leading to a further loss of\nnephrons. AST-120 delays the progression of CKD by removing serum indoxyl sulfate. Moreover, indoxyl sulfate induces oxidative stress in tubular cells, mesangial cells, vascular smooth muscle cells, endothelial cells and osteoblasts as well as stimulating aortic calcification in hypertensive rats, it is also involved in\nthe progression of CKD, cardiovascular disease (CVD) and osteodystrophy. Thus, the removal of indoxyl sulfate by AST-120 ameliorates the progression of not only CKD, but also of CVD and osteodystrophy.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_9_identifier_60":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2237/12904"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.18999/nagjms.72.1-2.1","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nagoya University School of Medicine","subitem_publisher_language":"en"}]},"item_9_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_9_source_id_61":{"attribute_name":"ISSN（Online）","attribute_value_mlt":[{"subitem_source_identifier":"2186-3326","subitem_source_identifier_type":"EISSN"}]},"item_9_source_id_7":{"attribute_name":"ISSN（print）","attribute_value_mlt":[{"subitem_source_identifier":"0027-7622","subitem_source_identifier_type":"PISSN"}]},"item_9_text_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_text_value":"application/pdf"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Niwa, Toshimitsu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"33472","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-20"}],"displaytype":"detail","filename":"p001-012_Niwa.pdf","filesize":[{"value":"432.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"p001-012_Niwa.pdf","objectType":"fulltext","url":"https://nagoya.repo.nii.ac.jp/record/11042/files/p001-012_Niwa.pdf"},"version_id":"97777993-20cc-468f-a90d-1cf0492eeb10"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Indoxyl sulfate","subitem_subject_scheme":"Other"},{"subitem_subject":"Chronic kidney disease","subitem_subject_scheme":"Other"},{"subitem_subject":"Protein metabolite theory","subitem_subject_scheme":"Other"},{"subitem_subject":"Oxidative stress","subitem_subject_scheme":"Other"},{"subitem_subject":"Oral adsorbent AST-120","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Uremic Toxicity of Indoxyl Sulfate","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Uremic Toxicity of Indoxyl Sulfate","subitem_title_language":"en"}]},"item_type_id":"9","owner":"17","path":["1196"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-03-11"},"publish_date":"2010-03-11","publish_status":"0","recid":"11042","relation_version_is_last":true,"title":["Uremic Toxicity of Indoxyl Sulfate"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-11-16T06:35:22.229409+00:00"}