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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 72(3-4)

Risk Factors of Recipient Receiving Living Donor Liver Transplantation in the Comprehensive Era of Indication and Perioperative Managements

https://doi.org/10.18999/nagjms.72.3-4.119
https://doi.org/10.18999/nagjms.72.3-4.119
667f89f8-70e6-4242-ab5d-cfd43ca2f091
名前 / ファイル ライセンス アクション
p119-128_Ishigami.pdf p119-128_Ishigami.pdf (253.2 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2010-09-21
タイトル
タイトル Risk Factors of Recipient Receiving Living Donor Liver Transplantation in the Comprehensive Era of Indication and Perioperative Managements
著者 Ishigami, Masatoshi

× Ishigami, Masatoshi

WEKO 38843

Ishigami, Masatoshi

Search repository
Katano, Yoshiaki

× Katano, Yoshiaki

WEKO 38844

Katano, Yoshiaki

Search repository
Hayashi, Kazuhiko

× Hayashi, Kazuhiko

WEKO 38845

Hayashi, Kazuhiko

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Ito, Akihiro

× Ito, Akihiro

WEKO 38846

Ito, Akihiro

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Hirooka, Yoshiki

× Hirooka, Yoshiki

WEKO 38847

Hirooka, Yoshiki

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Onishi, Yasuharu

× Onishi, Yasuharu

WEKO 38848

Onishi, Yasuharu

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Nakamura, Taro

× Nakamura, Taro

WEKO 38849

Nakamura, Taro

Search repository
Kiuchi, Tetsuya

× Kiuchi, Tetsuya

WEKO 38850

Kiuchi, Tetsuya

Search repository
Goto, Hidemi

× Goto, Hidemi

WEKO 38851

Goto, Hidemi

Search repository
キーワード
主題Scheme Other
主題 Risk factors
キーワード
主題Scheme Other
主題 LDLT
キーワード
主題Scheme Other
主題 Liver cirrhosis
キーワード
主題Scheme Other
主題 Prognosis
キーワード
主題Scheme Other
主題 Indication
抄録
内容記述 Living donor liver transplantation (LDLT) has become one of the chief methods of saving patients with end-stage liver disease due to liver cirrhosis. Accumulation of knowledge about indication and perioperative managements improve outcome of this treatment. In this study, we elucidate the risk factors of LDLT, which still exist today. Sixty-one patients received LDLT in our institute between 2003 and 2009 were included in this study. Recipient age and sex, donor age and sex, etiology, preoperative model of end-stage liver disease (MELD) score, hepatocellular carcinoma (HCC), graft versus recipient weight ratio (GRWR), cold and warm ischemic time, operation time, blood loss, ABO compatibility, rejection, cytomegalovirus (CMV) infection, biliary stricture, and calcineurin inhibitor (FK506 or cyclosporin A) were the factors investigated. p<0.05 was considered as statistically significant in the proportional hazard model. In univariate analysis, the recipients’age (p=0.024) and rejection episode (p=0.046) were selected as significant risk factors. In multivariate analysis including the factors that showed p<0.2 (recipient age, GRWR, ABO compatibility, rejection episode) in univariate analysis, recipient age (p=0.008, HR: 1.40; 95% CI: 1.09--1.80) and rejection episodes (p=0.002, HR: 13.33; 95% CI: 2.53--71.43) were still selected as significant independent risk factors after LDLT. Recipient age was shown to be 1.40 times risk per 1 year older and the rejection episode was shown to be 13.33 times risk in the recent era with comprehensive indication and preoperative management for LDLT. Indication must be cautious for elderly patients, and prevention of rejection is crucial for the improvement of results for LDLT.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.72.3-4.119
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 72, 号 3-4, p. 119-127, 発行日 2010-08
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/14173
識別子タイプ HDL
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